HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Aildenafil citrate: a new potent and highly selective phosphodiesterase type 5 inhibitor for the treatment of erectile dysfunction].

AbstractOBJECTIVE:
To evaluate the efficacy and safety of aildenafil citrate, an oral phosphodiesterase type 5 inhibitor, in the treatment of erectile dysfunction.
METHODS:
Integrated analyses were made of 8-week, randomized, double-blind, placebo-controlled phase 2 clinical trials involving 250 men with mild-to-severe erectile dysfunction of various etiologies who received aildenafil citrate 30 or 60 mg (n = 167) or placebo (n = 83).
RESULTS:
The statistic results of International Index of Erectile Function, Patient Sexual Encounter Profile (SEP) diaries and Global Assessment Question (GAQ) were significantly higher in the aildenafil citrate patients than in the placebo controls. The main drug-related adverse events were flushing, headache, dizziness and naupathia, which were mild and could be self-relieved.
CONCLUSION:
The aildenafil citrate therapy significantly ameliorated erectile function and was well tolerated by a wide range of patients with erectile dysfunction.
AuthorsZhan-ju He, Kai Zhang, Jie Jin, Ning-chen Li, Yan-qun Na, Wen-jun Bai, Xiao-feng Wang, Ji-chuan Zhu, Hui Jiang, Ren-pei Yuan, Bao-fa Hong, Tao Song, Yong Yang, Dong-xi Dai
JournalZhonghua nan ke xue = National journal of andrology (Zhonghua Nan Ke Xue) Vol. 12 Issue 12 Pg. 1080-3 (Dec 2006) ISSN: 1009-3591 [Print] China
PMID17201251 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Phosphodiesterase Inhibitors
  • Piperazines
  • Sulfones
  • aildenafil
Topics
  • Administration, Oral
  • Double-Blind Method
  • Drug Administration Schedule
  • Erectile Dysfunction (drug therapy)
  • Humans
  • Male
  • Phosphodiesterase Inhibitors (adverse effects, therapeutic use)
  • Piperazines (adverse effects, therapeutic use)
  • Sulfones (adverse effects, therapeutic use)
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: