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Long-term efficacy and safety of very-low-dose amiodarone treatment for the maintenance of sinus rhythm in patients with chronic atrial fibrillation after successful direct-current cardioversion.

AbstractBACKGROUND:
Long-term maintenance of sinus rhythm after successful conversion of chronic atrial fibrillation (CAF), often ameliorates patients' symptoms, reduces the risk of ischemic stroke and improves cardiovascular hemodynamics. This prospective study aims to evaluate the long-term efficacy and safety of very low-dose amiodarone (100 mg daily) for the maintenance of sinus rhythm after successful direct-current (DC) cardioversion in patients with CAF and rheumatic heart disease (RHD) post intervention.
METHODS:
This study was a randomized prospective trial. One day after successful DC cardioversion (remained normal sinus rhythm) in patients with CAF and RHD post intervention for more than six months and adequate anticoagulation, all were randomly administered either amiodarone 200 mg daily in group A or amiodarone 100 mg daily in group B.
RESULTS:
A total of 76 patients (40 men and 36 women) were examined from February 1998 to December 1999. The mean age of the patients was (66 +/- 10) years, and the mean follow-up was (67 +/- 8) months (range 61 to 84 months). Actuarial rates of the maintenance of sinus rhythm were similar in the two groups after 5 years of follow-up. Four patients (11%) in group A but none in group B experienced significant adverse effects that necessitated withdrawal of amiodarone. No death occurred during the study period.
CONCLUSION:
A very low dose of amiodarone results in adequate long-term efficacy and is safe for maintaining sinus rhythm in patients with CAF and RHD post intervention after successful DC cardioversion.
AuthorsGwo-ping Jong, Mu-hsin Chang, Ting-chuan Chang, Pesus Chou, Chong-yau Fu, Li-yun Tien, Chung-yin Chen, Tso-chiang Ma
JournalChinese medical journal (Chin Med J (Engl)) Vol. 119 Issue 24 Pg. 2030-5 (Dec 20 2006) ISSN: 0366-6999 [Print] China
PMID17199952 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Arrhythmia Agents
  • Amiodarone
Topics
  • Aged
  • Amiodarone (administration & dosage, adverse effects)
  • Anti-Arrhythmia Agents (administration & dosage)
  • Arrhythmia, Sinus (drug therapy)
  • Atrial Fibrillation (drug therapy, physiopathology)
  • Chronic Disease
  • Cohort Studies
  • Electric Countershock (methods)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies

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