Abstract | BACKGROUND: METHODS: This was a clinical trial on patients who received intravenous mitoxantrone, 12 mg/m2 every 3 months. The study was performed at Isfahan Multiple Sclerosis Clinics, affiliated to Isfahan University of Medical Sciences. This clinical trial was conducted from October 2003 through April 2005. One hundred and forty-seven patients with worsening relapsing-remitting and secondary progressive multiple sclerosis received mitoxantrone, 12 mg/m(2) every 3 months. Clinical assessment was made every 3 months for one year. RESULTS: Of the 147 patients, 129 (93 females and 36 males) could successfully complete the course of our study. A significant therapeutic effect (P < 0.0001) was detected for the attack rate before and after treatment. The Mean attack rate 12 months before treatment was 1.10 (SD = 0.95), which reduced to 0.09 (SD = 0.29) during treatment. The Mean expanded disability status scale at the beginning of the treatment was 4.32, which declined to 3.62 (P < 0.0001) after one year. CONCLUSION:
Mitoxantrone was generally well tolerated and reduced progression of disability and clinical exacerbation in our patients. Physicians must be careful about the complications of mitoxantrone especially cardiotoxicity.
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Authors | Ali Hamzehloo, Masood Etemadifar |
Journal | Archives of Iranian medicine
(Arch Iran Med)
Vol. 10
Issue 1
Pg. 59-64
(Jan 2007)
ISSN: 1029-2977 [Print] Iran |
PMID | 17198456
(Publication Type: Clinical Trial, Journal Article, Multicenter Study)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Analgesics
(administration & dosage, therapeutic use)
- Disability Evaluation
- Disease Progression
- Female
- Follow-Up Studies
- Humans
- Incidence
- Infusions, Intravenous
- Iran
(epidemiology)
- Male
- Middle Aged
- Mitoxantrone
(administration & dosage, therapeutic use)
- Multiple Sclerosis
(drug therapy, epidemiology, therapy)
- Retrospective Studies
- Treatment Outcome
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