Abstract | PURPOSE: METHODS: RESULTS: The 50% inhibitory concentration of acyclovir and trifluorothymidine for the isolated HSV strain was 13.75 and 0.28 microg/mL, respectively, indicating that the virus was resistant to acyclovir. DNA sequencing of the viral thymidine kinase revealed that this virus had a frameshift mutant with a G insertion in the 7Gs homopolymer. Topical trifluorothymidine was effective, and the epithelial lesion was completely resolved within 2 weeks. CONCLUSION:
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Authors | Wei Zhang, Takashi Suzuki, Atsushi Shiraishi, Ichiroh Shimamura, Yoshitsugu Inoue, Yuichi Ohashi |
Journal | Cornea
(Cornea)
Vol. 26
Issue 1
Pg. 105-6
(Jan 2007)
ISSN: 0277-3740 [Print] United States |
PMID | 17198024
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
- Antiviral Agents
- DNA, Viral
- Thymidine Kinase
- Acyclovir
|
Topics |
- Acyclovir
(therapeutic use)
- Aged
- Antiviral Agents
(therapeutic use)
- DNA, Viral
(analysis)
- Drug Resistance, Viral
- Frameshift Mutation
- Humans
- Keratitis, Dendritic
(drug therapy, virology)
- Male
- Simplexvirus
(drug effects, genetics)
- Thymidine Kinase
(genetics)
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