Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: The first randomized controlled trial of adult male circumcision found a highly significant 60% reduction in HIV incidence among men in the intervention arm. Modelling this effect predicts that widespread implementation of male circumcision could avert 2 million HIV infections over the next decade in sub-Saharan Africa. The biological rationale is that the foreskin increases risk of HIV infection due to the high density of HIV target cells and lack of keratinization of the inner mucosal surface. SUMMARY: There is strong evidence that male circumcision reduces risk of HIV, syphilis and chancroid. If results are confirmed by two ongoing trials in sub-Saharan Africa, provision of safe male circumcision could be added to HIV prevention packages in high-incidence settings. This would also provide an opportunity for HIV-prevention education and counselling to young men at high risk of infection.
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Authors | Helen A Weiss |
Journal | Current opinion in infectious diseases
(Curr Opin Infect Dis)
Vol. 20
Issue 1
Pg. 66-72
(Feb 2007)
ISSN: 0951-7375 [Print] United States |
PMID | 17197884
(Publication Type: Journal Article, Review)
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Topics |
- Circumcision, Male
- HIV Infections
(epidemiology, prevention & control, transmission)
- Humans
- Male
- Sexually Transmitted Diseases
(epidemiology, prevention & control, transmission)
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