| Abstract | BACKGROUND: The authors examine the role of dental disease and nonsurgical dental procedures in the incidence and duration of bacteremia in children. METHODS: The authors randomized a group of children to receive amoxicillin or a placebo before dental rehabilitation in an operating room setting. They collected eight blood draws at the following times: two minutes after intubation (draw 1); after dental restorations, pulp therapy and cleaning (draw 2); 10 minutes later (draw 3); and five draws during and after dental extractions (draws 4-8). The authors compared dental disease parameters and the type of dental procedures performed with the incidence and duration of bacteremia. RESULTS: The authors enrolled 100 children (aged 1-8 years) in the study. The incidence of bacteremia from draw 2 was 20 percent in the placebo group and 6 percent in the amoxicillin group (P = .07), and the incidence from draw 3 was 16 percent in the placebo group and zero percent in the amoxicillin group (P = .03). Subjects with higher gingival scores were more likely to have a bacteremia for draw 2 (P = .01). The authors found that subjects in the group with bacteremia for draw 3 had undergone more pulpotomies than did subjects in the group without bacteremia for draw 3 (3 +/- 2.5 standard deviation [SD] versus 1.5 +/- 1.6 SD, P = .04), while they found almost no differences for draw 2. CONCLUSIONS: This study suggests that gingival disease has an impact on bacteremia after dental restorations and prophylaxis. Although antibiotics have an impact, they do not eliminate bacteremia altogether. |
| Authors | Michael T Brennan, M Louise Kent, Philip C Fox, H James Norton, Peter B Lockhart
(Affiliation: Department of Oral Medicine, Carolinas Medical Center, P.O. Box 32861, Charlotte, NC 28232, USA. mike.brennan at carolinas.org)
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| Journal | Journal of the American Dental Association (1939)
(J Am Dent Assoc)
Vol. 138
Issue 1
Pg. 80-5
(Jan 2007)
ISSN: 0002-8177 United States |
| PMID | 17197406
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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| Chemical References |
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| Topics |
- Amoxicillin
(therapeutic use)
- Antibiotic Prophylaxis
- Bacteremia
(etiology)
- Child
- Child, Preschool
- Dental Care
- Dental Caries
(complications)
- Dental Prophylaxis
- Dental Restoration, Permanent
- Female
- Gingival Diseases
(complications)
- Humans
- Infant
- Intubation, Intratracheal
- Male
- Periodontal Diseases
(complications)
- Placebos
- Pulpectomy
- Pulpotomy
- Time Factors
- Tooth Diseases
(complications, therapy)
- Tooth Extraction
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