Abstract | BACKGROUND: METHODS: We prospectively studied 95 children with IPD, and blood and cerebrospinal fluid (CSF) samples were taken at admission for the determination of chemokines, interferon-gamma (IFNgamma), and pneumococcal bacterial loads. RESULTS: Plasma CXCL8 and CCL2, CSF CXCL8 and CCL4, and IFNgamma were significantly higher in HIV-infected children than in HIV-uninfected children. Blood and CSF pneumococcal bacterial loads correlated with plasma and CSF chemokines, respectively, and were higher in HIV-infected children compared with HIV-uninfected children. Among HIV-infected children, plasma concentrations of CXCL8 and CCL2 were significantly higher in nonsurvivors than in survivors, but CCL5 was significantly lower. HIV-infected and HIV-uninfected children with IPD had higher concentrations of chemokines (except CCL5) than acutely ill HIV-infected and HIV-uninfected children with no detectable bacterial infection. Male gender and low plasma CCL2 concentrations were shown to be independently associated with survival. CONCLUSIONS:
Chemokines, in particular CCL2, are associated with survival in IPD and correlate with pneumococcal bacterial loads, disease presentation, and outcome.
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Authors | Enitan D Carrol, Limangeni A Mankhambo, Paul Balmer, Standwell Nkhoma, Daniel L Banda, Malcolm Guiver, Graham Jeffers, Nick Makwana, Elizabeth M Molyneux, Malcolm E Molyneux, Rosalind L Smyth, C Anthony Hart, Invasive Pneumococcal Disease Study Group |
Journal | Journal of acquired immune deficiency syndromes (1999)
(J Acquir Immune Defic Syndr)
Vol. 44
Issue 4
Pg. 443-50
(Apr 01 2007)
ISSN: 1525-4135 [Print] United States |
PMID | 17195767
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- CCL4 protein, human
- CCL5 protein, human
- Chemokine CCL2
- Chemokine CCL4
- Chemokine CCL5
- Chemokines
- Chemokines, CC
- DNA, Bacterial
- Interleukin-8
- Interferon-gamma
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Topics |
- Adolescent
- Anti-Bacterial Agents
(therapeutic use)
- Chemokine CCL2
(blood, cerebrospinal fluid)
- Chemokine CCL4
- Chemokine CCL5
- Chemokines
(blood, cerebrospinal fluid)
- Chemokines, CC
(blood, cerebrospinal fluid)
- Child
- Child, Preschool
- DNA, Bacterial
(analysis, genetics)
- HIV Infections
(blood, cerebrospinal fluid)
- Humans
- Infant
- Interferon-gamma
(blood, cerebrospinal fluid)
- Interleukin-8
(blood, cerebrospinal fluid)
- Pneumococcal Infections
(blood, cerebrospinal fluid, drug therapy)
- Polymerase Chain Reaction
- Streptococcus pneumoniae
(drug effects, genetics)
- Survival Analysis
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