Abstract |
Epidemiological studies have linked high levels (>200 microg/L) of chronic exposure to arsenic in drinking-water with elevated risks of several vascular diseases. In this pilot study, the association between low-level arsenic exposure and carotid artery intimal-medial thickness (IMT) was evaluated among 66 healthy, normotensive, relatively young individuals (mean age 35 years) participating in the ongoing Health Effects of Arsenic Longitudinal Study in Bangladesh. Participants with a higher carotid IMT (>0.75 mm) in general had higher levels of past chronic exposure of arsenic than those with a lower carotid IMT (< or = 0.75 mm). Although the differences in average arsenic exposure between the two groups were not statistically significant, the findings suggest a possible association between low-level arsenic exposure from drinking-water and carotid atherosclerosis, warranting the need for larger studies.
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Authors | Yu Chen, Mohammad Enamul Hakim, Faruque Parvez, Tariqul Islam, Atiar M Rahman, Habibul Ahsan |
Journal | Journal of health, population, and nutrition
(J Health Popul Nutr)
Vol. 24
Issue 2
Pg. 253-7
(Jun 2006)
ISSN: 1606-0997 [Print] Bangladesh |
PMID | 17195567
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Water Pollutants, Chemical
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Topics |
- Adult
- Age Distribution
- Arsenic Poisoning
(complications, epidemiology, prevention & control, urine)
- Bangladesh
(epidemiology)
- Carotid Arteries
(diagnostic imaging, pathology)
- Carotid Artery Diseases
(chemically induced, diagnosis, epidemiology)
- Chi-Square Distribution
- Chronic Disease
- Environmental Exposure
(adverse effects, analysis, statistics & numerical data)
- Epidemiologic Studies
- Female
- Follow-Up Studies
- Humans
- Logistic Models
- Male
- Pilot Projects
- Population Surveillance
- Risk Factors
- Tunica Intima
(diagnostic imaging, pathology)
- Ultrasonography
- Water Pollutants, Chemical
(adverse effects, analysis)
- Water Supply
(analysis, statistics & numerical data)
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