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Arsenic exposure from drinking-water and carotid artery intima-medial thickness in healthy young adults in Bangladesh.

Abstract
Epidemiological studies have linked high levels (>200 microg/L) of chronic exposure to arsenic in drinking-water with elevated risks of several vascular diseases. In this pilot study, the association between low-level arsenic exposure and carotid artery intimal-medial thickness (IMT) was evaluated among 66 healthy, normotensive, relatively young individuals (mean age 35 years) participating in the ongoing Health Effects of Arsenic Longitudinal Study in Bangladesh. Participants with a higher carotid IMT (>0.75 mm) in general had higher levels of past chronic exposure of arsenic than those with a lower carotid IMT (< or = 0.75 mm). Although the differences in average arsenic exposure between the two groups were not statistically significant, the findings suggest a possible association between low-level arsenic exposure from drinking-water and carotid atherosclerosis, warranting the need for larger studies.
AuthorsYu Chen, Mohammad Enamul Hakim, Faruque Parvez, Tariqul Islam, Atiar M Rahman, Habibul Ahsan
JournalJournal of health, population, and nutrition (J Health Popul Nutr) Vol. 24 Issue 2 Pg. 253-7 (Jun 2006) ISSN: 1606-0997 [Print] Bangladesh
PMID17195567 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
Chemical References
  • Water Pollutants, Chemical
Topics
  • Adult
  • Age Distribution
  • Arsenic Poisoning (complications, epidemiology, prevention & control, urine)
  • Bangladesh (epidemiology)
  • Carotid Arteries (diagnostic imaging, pathology)
  • Carotid Artery Diseases (chemically induced, diagnosis, epidemiology)
  • Chi-Square Distribution
  • Chronic Disease
  • Environmental Exposure (adverse effects, analysis, statistics & numerical data)
  • Epidemiologic Studies
  • Female
  • Follow-Up Studies
  • Humans
  • Logistic Models
  • Male
  • Pilot Projects
  • Population Surveillance
  • Risk Factors
  • Tunica Intima (diagnostic imaging, pathology)
  • Ultrasonography
  • Water Pollutants, Chemical (adverse effects, analysis)
  • Water Supply (analysis, statistics & numerical data)

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