| Abstract | THE AIM: of this study is to investigate the prevalence of diabetes-related autoantibodies in a group of children with celiac disease and to compare it with a control group. MATERIAL AND METHODS: We recruited 31 celiac children at diagnosis (on gluten containing diet) and 31 age and sex matched healthy children. Anti-islet cell antibodies (ICA) were detected by indirect immunofluorescence on monkey pancreas. Anti-glutamate decarboxylase (anti-GAD) and anti-tyrosine phosphatase (anti-IA2) antibodies were assessed by a radio-immuno- precipitation method. RESULTS: Three out of 31 celiac patients (9.7%) had one or more diabetes-related autoantibodies. ICA, anti-GAD and anti-IA2 were found in respectively 3.2%; 3.2% and 9.7% of patients. Only one control (3.2%) had anti-GAD. There was no statistically significant difference between the 2 groups. CONCLUSION: The risk to develop diabetes seems to be the same in celiac patients and in healthy subjects thus screening of diabetes-related autoantibodies is not justified in celiac patients. |
| Authors | L Laadhar, M Ben Hariz, M Zitouni, M Sellami-Kallel, A Toumi, A Mehrezi, S Makni
(Affiliation: Laboratoire d'Immunologie, hôpital La Rabta, 1007 Tunis, Tunisia. lilia_laadhar at yahoo.com)
|
| Journal | Annales d'endocrinologie
(Ann Endocrinol (Paris))
Vol. 67
Issue 6
Pg. 588-90
(Dec 2006)
ISSN: 0003-4266 France |
| Vernacular Title | Prévalence des marqueurs sérologiques du diabète de type 1 chez les enfants atteints de maladie coeliaque. |
| PMID | 17194969
(Publication Type: English Abstract, Journal Article)
|
| Chemical References |
- Autoantibodies
- islet cell antibody
- Protein Tyrosine Phosphatases
- Glutamate Decarboxylase
|
| Topics |
- Autoantibodies
(blood)
- Celiac Disease
(blood, immunology)
- Child
- Diabetes Mellitus
(blood, immunology)
- Female
- Glutamate Decarboxylase
(immunology)
- Humans
- Islets of Langerhans
(immunology)
- Protein Tyrosine Phosphatases
(immunology)
- Reference Values
|
