Abstract |
A highly efficient BF3.OEt2-catalyzed formal dehydration C-C coupling reaction between readily available alpha-EWG ketene-(S,S)- acetals and various alcohols via direct substitution of the hydroxy group in alcohols has been developed. On the basis of this C-C coupling reaction, a series of alkylated alpha-EWG ketene-(S,S)- acetals and functionalized 1,4-pentanedienes were prepared in high to excellent yields and the unsymmetrical biaryls were synthesized in good yields from the generated 1,4-pentanedienes and nitroalkanes through a one-pot annulation-aromatization process.
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Authors | Qian Zhang, Shaoguang Sun, Jianglei Hu, Qun Liu, Jing Tan |
Journal | The Journal of organic chemistry
(J Org Chem)
Vol. 72
Issue 1
Pg. 139-43
(Jan 05 2007)
ISSN: 0022-3263 [Print] United States |
PMID | 17194092
(Publication Type: Journal Article)
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