A potential prebiotic route to adenine from hypoxanthine.

Abstract	A possible reaction mechanism for the dehydration of glycinamide (3) and N,N'-diformylurea (4) yielding hypoxanthine (2) has been investigated. Furthermore, a potential prebiotic route converting hypoxanthine (2) into adenine (1) via phosphate activation followed by substitution reaction with NH3 was studied. This reaction mimics the proposed biochemical mechanism for the conversion of IMP to AMP.
Authors	Irene M Lagoja, Piet Herdewijn
Journal	Chemistry & biodiversity (Chem Biodivers) Vol. 2 Issue 7 Pg. 923-7 (Jul 2005) ISSN: 1612-1880 [Electronic] Switzerland
PMID	17193183 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	N,N'-diformylurea Xanthine Hypoxanthine glycine amide Guanine Urea isoguanine Adenine Glycine
Topics	Adenine (chemical synthesis) Glycine (analogs & derivatives, chemistry) Guanine (chemistry) Hypoxanthine (chemistry) Molecular Structure Urea (analogs & derivatives, chemistry) Xanthine (chemistry)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!