Abstract | OBJECTIVE: DATA SOURCES: STUDY SELECTION AND DATA EXTRACTION: All English language articles that were identified from the search were evaluated. All primary literature was included in the review. DATA SYNTHESIS: In several case reports and most clinical trials, patients with anorexia nervosa successfully gained weight while being treated with olanzapine. Moreover, many patients treated with olanzapine achieved a healthy body weight. Case reports and trials identified additional benefits of olanzapine, including reduction in delusional thinking; improvement in body image, sleep, depressive symptoms, adherence to treatment, and eating-disorder symptoms; and decreased agitation and premeal anxiety. CONCLUSIONS: Preliminary evidence supports the use of olanzapine for treatment of anorexia nervosa by demonstrating that olanzapine 2.5-15 mg daily promotes weight gain and has positive effects on associated psychological symptoms. Limitations of the reported data include small sample size, low completion rate in clinical trials, and open-label trial design. Although olanzapine appears to have a potential role in the treatment of anorexia nervosa that has been unresponsive to other therapy, randomized, placebo-controlled studies with larger sample sizes are necessary to establish its role in therapy.
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Authors | Kaelen C Dunican, Dana DelDotto |
Journal | The Annals of pharmacotherapy
(Ann Pharmacother)
Vol. 41
Issue 1
Pg. 111-5
(Jan 2007)
ISSN: 1542-6270 [Electronic] United States |
PMID | 17190846
(Publication Type: Journal Article, Review)
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Chemical References |
- Benzodiazepines
- Olanzapine
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Topics |
- Anorexia Nervosa
(drug therapy, epidemiology, psychology)
- Benzodiazepines
(therapeutic use)
- Humans
- Olanzapine
- Treatment Outcome
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