Photoreceptor status after resolved macular edema in branch retinal vein occlusion treated with tissue plasminogen activator.

To evaluate the integrity of photoreceptors in macular edema (ME) associated with branch retinal vein occlusion after intravitreal tissue plasminogen activator.
Retrospective, interventional case series.
Nineteen eyes with ME by branch retinal vein occlusion were treated with intravitreal tissue plasminogen activator injection. We assessed visual acuity (VA) and the presence or absence in the fovea of a third high reflectance band (HRB) by optical coherence tomography at the final visit.
No differences were found in age, preoperative VA, and foveal thickness between the groups with or without the third HRB. After treatment, the mean VA improved significantly (P < .05) in both groups. At the final visit, the mean VA in the group without HRB was significantly poorer than the group with HRB (P = .0042); foveal thickness did not differ between the groups.
The integrity of the third HRB in the fovea is associated with VA after the resolution of ME.
AuthorsTomoaki Murakami, Akitaka Tsujikawa, Masafumi Ohta, Kazuaki Miyamoto, Mihori Kita, Daiseke Watanabe, Hitoshi Takagi, Nagahisa Yoshimura
JournalAmerican journal of ophthalmology (Am J Ophthalmol) Vol. 143 Issue 1 Pg. 171-3 (Jan 2007) ISSN: 0002-9394 [Print] United States
PMID17188062 (Publication Type: Journal Article)
Chemical References
  • Fibrinolytic Agents
  • Tissue Plasminogen Activator
  • Female
  • Fibrinolytic Agents (therapeutic use)
  • Fovea Centralis
  • Humans
  • Injections
  • Macular Edema (drug therapy, etiology)
  • Male
  • Middle Aged
  • Photoreceptor Cells, Vertebrate (pathology)
  • Retinal Vein Occlusion (complications)
  • Retrospective Studies
  • Tissue Plasminogen Activator (therapeutic use)
  • Tomography, Optical Coherence
  • Venous Pressure
  • Visual Acuity (physiology)
  • Vitreous Body

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