Regulation of calcitonin release from the 6.23 rat C-cell line by cyclic nucleotide analogues and pharmacological mediators.

Abstract

Calcitonin release from 6.23 rat medullary thyroid carcinoma C-cells was stimulated by dibutyryl cyclic AMP and inhibited by dibutyryl cyclic GMP in concentration dependent fashion. Histamine, isoproterenol, prostaglandin E2 and Bay K 8644 stimulated calcitonin release, while acetylcholine and serotonin had no significant effect on CT release.

• Authors: J L Gilgenkrantz, T J Hall, T J Chambers
• Journal: Experientia (Experientia) Vol. 47 Issue 10 Pg. 1067-9 (Oct 15 1991) ISSN: 0014-4754 [Print] Switzerland
• PMID: 1718775 (Publication Type: Journal Article)

Chemical References

• Dibutyryl Cyclic GMP
• Bucladesine
• 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
• Histamine
• Calcitonin
• Dinoprostone
• Isoproterenol

Topics

• 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester (pharmacology)
• Animals
• Bucladesine (pharmacology)
• Calcitonin (metabolism)
• Carcinoma (metabolism)
• Dibutyryl Cyclic GMP (pharmacology)
• Dinoprostone (pharmacology)
• Histamine (pharmacology)
• Isoproterenol (pharmacology)
• Rats
• Thyroid Neoplasms (metabolism)
• Tumor Cells, Cultured