| Abstract | OBJECTIVE: Risperidone in antipsychotic doses induces hyperprolactinemia. The aim of this study was to verify whether the same is true for low doses of risperidone (0.5-2 mg per day) added to antidepressants or anxiolytics. METHODS: Prolactin levels were measured in 4 men (mean age 49.5+/-19.1 years) and 8 women (mean age 31.3+/-8.2 years) inpatients with depressive and anxiety disorders who were treated with risperidone (median doses per day 1.25 mg) for median 15.5 days as an augmentation treatment to antidepressants (n=8), anxiolytics (n=6) and mood stabilizers (n=2). RESULTS: 11 of 12 patients had hyperprolactinemia. Median plasma prolactin level was 1598 mIU/ml, 95% CI 1 040-2 661 mIU/ml. Significant correlation between risperidone daily dose and plasma prolactin level (Spearman's R=0.655, p=0.02) was detected. Two women suffered from galactorrhea and one from amenorrhea. CONCLUSIONS: Even low doses of risperidone used as an augmentation to antidepressants or benzodiazepines are associated with hyperprolactinemia and can induce endocrinological side effects. The co-medication of antidepressants and benzodiazepines can potentially increase intensity of prolactinemia. |
| Authors | Miloslav Kopecek, Martin Bares, Jirí Horacek, Pavel Mohr
(Affiliation: Prague Psychiatric Centre, 3rd Medical Faculty Prague - Charles University, Centre of Neuropsychiatric Studies in Prague, Prague, Czech Republic. kopecek at pcp.lf3.cuni.cz)
|
| Journal | Neuro endocrinology letters
(Neuro Endocrinol Lett)
Vol. 27
Issue 6
Pg. 803-6
(Dec 2006)
ISSN: 0172-780X Sweden |
| PMID | 17187006
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Anti-Anxiety Agents
- Antidepressive Agents
- Antipsychotic Agents
- Benzodiazepines
- Risperidone
- Prolactin
|
| Topics |
- Adult
- Anti-Anxiety Agents
(administration & dosage, therapeutic use)
- Antidepressive Agents
(administration & dosage, therapeutic use)
- Antipsychotic Agents
(administration & dosage, adverse effects)
- Anxiety
(blood, drug therapy)
- Benzodiazepines
(administration & dosage, therapeutic use)
- Depressive Disorder
(blood, drug therapy)
- Dose-Response Relationship, Drug
- Drug Therapy, Combination
- Female
- Humans
- Hyperprolactinemia
(chemically induced)
- Male
- Middle Aged
- Prolactin
(blood)
- Risperidone
(administration & dosage, adverse effects)
- Statistics, Nonparametric
|
