Abstract | BACKGROUND: METHODS AND RESULTS: Four weeks after left coronary artery ligation, 50 Sprague-Dawley rats were assigned to 5 groups (n=10, each). Control group had a gelatin sheet (20x20 mm) containing saline applied to the infarct area, whereas the 4 treatment groups had gelatin sheets incorporating erythropoietin 0.1 U, 1 U, 10 U and 100 U, respectively. Endpoint measurements performed at 8 weeks after the coronary ligation revealed that the fractional area change was larger for erythropoietin 1 U and 10 U than in the other 3 groups. The LV end-systolic elastance and the time constant of isovolumic relaxation were better for erythropoietin 1 U and 10 U than in the other 3 groups. The density of vessels larger than 50 microm in diameter was the highest in the erythropoietin 1 U group. The number of red blood cells was significantly increased in groups receiving erythropoietin 10 U and 100 U. CONCLUSIONS:
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Authors | Xue Lin, Masatoshi Fujita, Naoki Kanemitsu, Yu Kimura, Keiichi Tambara, Goditha U Premaratne, Atsushi Nagasawa, Tadashi Ikeda, Yasuhiko Tabata, Masashi Komeda |
Journal | Circulation journal : official journal of the Japanese Circulation Society
(Circ J)
Vol. 71
Issue 1
Pg. 132-7
(Jan 2007)
ISSN: 1346-9843 [Print] Japan |
PMID | 17186991
(Publication Type: Evaluation Study, Journal Article)
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Chemical References |
- Delayed-Action Preparations
- Erythropoietin
- Gelatin
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Topics |
- Animals
- Delayed-Action Preparations
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Echocardiography
- Erythropoietin
(administration & dosage, pharmacology, therapeutic use)
- Gelatin
- Heart
(drug effects, physiology)
- Male
- Myocardial Infarction
(drug therapy, physiopathology)
- Neovascularization, Physiologic
(drug effects)
- Polycythemia
(physiopathology, prevention & control)
- Rats
- Rats, Sprague-Dawley
- Ventricular Dysfunction, Left
(drug therapy, physiopathology)
- Ventricular Remodeling
(drug effects)
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