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Sustained-release erythropoietin ameliorates cardiac function in infarcted rat-heart without inducing polycythemia.

AbstractBACKGROUND:
The usefulness of sustained-release erythropoietin for improving left ventricular (LV) function without polycythemia was evaluated in a rat chronic myocardial infarction model.
METHODS AND RESULTS:
Four weeks after left coronary artery ligation, 50 Sprague-Dawley rats were assigned to 5 groups (n=10, each). Control group had a gelatin sheet (20x20 mm) containing saline applied to the infarct area, whereas the 4 treatment groups had gelatin sheets incorporating erythropoietin 0.1 U, 1 U, 10 U and 100 U, respectively. Endpoint measurements performed at 8 weeks after the coronary ligation revealed that the fractional area change was larger for erythropoietin 1 U and 10 U than in the other 3 groups. The LV end-systolic elastance and the time constant of isovolumic relaxation were better for erythropoietin 1 U and 10 U than in the other 3 groups. The density of vessels larger than 50 microm in diameter was the highest in the erythropoietin 1 U group. The number of red blood cells was significantly increased in groups receiving erythropoietin 10 U and 100 U.
CONCLUSIONS:
Gelatin hydrogel sheets incorporating 1 U erythropoietin improved LV function without inducing polycythemia in a rat chronic myocardial infarction model.
AuthorsXue Lin, Masatoshi Fujita, Naoki Kanemitsu, Yu Kimura, Keiichi Tambara, Goditha U Premaratne, Atsushi Nagasawa, Tadashi Ikeda, Yasuhiko Tabata, Masashi Komeda
JournalCirculation journal : official journal of the Japanese Circulation Society (Circ J) Vol. 71 Issue 1 Pg. 132-7 (Jan 2007) ISSN: 1346-9843 [Print] Japan
PMID17186991 (Publication Type: Evaluation Study, Journal Article)
Chemical References
  • Delayed-Action Preparations
  • Erythropoietin
  • Gelatin
Topics
  • Animals
  • Delayed-Action Preparations
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Echocardiography
  • Erythropoietin (administration & dosage, pharmacology, therapeutic use)
  • Gelatin
  • Heart (drug effects, physiology)
  • Male
  • Myocardial Infarction (drug therapy, physiopathology)
  • Neovascularization, Physiologic (drug effects)
  • Polycythemia (physiopathology, prevention & control)
  • Rats
  • Rats, Sprague-Dawley
  • Ventricular Dysfunction, Left (drug therapy, physiopathology)
  • Ventricular Remodeling (drug effects)

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