[Clinical and pathological study on effects of Qianggan Capsule combined lamivudine on hepatic fibrosis in patients with chronic hepatitis B].

Abstract

OBJECTIVE:

To study the therapeutic effects of Qianggan Capsule (QC) combined Lamivudine on hepatic fibrosis in patients with chronic hepatitis B.

METHODS:

Eighty-five patients were randomly divided into two groups, group A (40 cases) were treated with QC and Lamivudine and group B (45 cases) were treated with QC alone both for 6 months. Hepatic fibrosis related indexes and pathologic examination of liver biopsy were performed within 3 months before treatment and in 1 month after treatment.

RESULTS:

Serum levels of hyaluronic acid, collagen N and laminin decreased markedly after treatment in both groups (P < 0.05). Hepatic histopathological examination showed that the total effective rate of impovement in activity of inflammation-necrosis and fibrosis was 80.0% and 70.0% in group A, 57.8% and 75.6% in group B, respectively, the combined treatment showed a better effect in improving the activity of inflammation-necrosis than QC alone (P < 0.05), but with no significant difference to the latter in improving fibrosis.

CONCLUSION:

QC combined Lamivudine could markedly reduce the activity of hepatic inflammation-necrosis, QC alone could also improve hepatic fibrosis.

• Authors: Hua Wang, Yan-long Zhao, Ke-cheng Xu
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 26 Issue 11 Pg. 978-80 (Nov 2006) ISSN: 1003-5370 [Print] China
• PMID: 17186724 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Capsules
• Drugs, Chinese Herbal
• Reverse Transcriptase Inhibitors
• qianggan
• Lamivudine

Topics

• Adult
• Capsules
• Drug Therapy, Combination
• Drugs, Chinese Herbal (therapeutic use)
• Female
• Hepatitis B, Chronic (complications, drug therapy)
• Humans
• Lamivudine (therapeutic use)
• Liver (drug effects, pathology, virology)
• Liver Cirrhosis (drug therapy, etiology)
• Male
• Middle Aged
• Phytotherapy
• Reverse Transcriptase Inhibitors (therapeutic use)
• Treatment Outcome