Pro-oxidant effects of Mebendazole in albino rats experimentally infected with Trichinella spiralis.

Abstract

Trichinellosis treated with Mebendazole often leads to complications in the course of the disease in humans and animals as a result of intoxication and hyper-sensitization of an organism due to the massive destruction of parasites. This study was conducted to research Mebendazole incidence on lipid peroxidation processes (LPP) in rats' blood in Trichinella spiralis-infected and parasite-free albino rats. The research was conducted to evaluate erythrocyte superoxide dismutase (SOD) activity and malonic dialdehyde (MDA) concentration in blood serum. The parameters of the SOD-MDA system in infected albino rats, which were treated or untreated with Mebendazole were analyzed. It was concluded that Mebendazole amplifies the LPP in the blood of both infected and parasite-free animals: in a dose of 150 mg/kg anthelmintic causes disturbances of biochemical homeostasis in the SOD-MDA system, thus working as a pro-oxidant.

• Authors: V A Tolstoj, A Lytvynets, I Langrova
• Journal: Parasitology research (Parasitol Res) Vol. 100 Issue 6 Pg. 1277-80 (May 2007) ISSN: 0932-0113 [Print] Germany
• PMID: 17186274 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Malondialdehyde
• Mebendazole
• Superoxide Dismutase

Topics

• Animals
• Lipid Peroxidation
• Male
• Malondialdehyde (metabolism)
• Mebendazole (pharmacology)
• Rats
• Rats, Wistar
• Superoxide Dismutase (metabolism)
• Trichinella spiralis
• Trichinellosis (drug therapy)