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Critical role of physiologist John A. Johnson in the origins of Minnesota's billion dollar pacemaker industry.

AbstractComplete heart block developed in more than 10% of C. Walton Lillehei's early patients undergoing closure of ventricular septal defects, and hospital mortality was 100% in this group of patients. This problem of early fatality from heart block was completely eliminated with the use of a myocardial electrode in combination with an external plug-in electric stimulator. This method of treatment, suggested by Dr John A. Johnson, a professor of physiology at the University of Minnesota, was first used by Dr Lillehei on January 30, 1957. The next 3 years would witness the development of a portable, external, battery-powered pacemaker, and then an implantable pacemaker available for thousands of patients susceptible to lethal Stokes-Adams attacks. Fifty years have passed, and in 2005, approximately 800,000 pacemakers were implanted worldwide.
AuthorsVincent L Gott (Affiliation: Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA. vgott at csurg.jhmi.jhu.edu)
JournalThe Annals of thoracic surgery (Ann Thorac Surg) Vol. 83 Issue 1 Pg. 349-53 (Jan 2007) ISSN: 1552-6259 Netherlands
PMID17184706 (Publication Type: Biography, Historical Article, Journal Article, Research Support, Non-U.S. Gov't)
Topics
  • Cardiac Pacing, Artificial
  • History, 20th Century
  • Humans
  • Industry
  • Pacemaker, Artificial (history)
  • Physiology