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Collagen XVIII modulation is altered during progression of oral dysplasia and carcinoma.

AbstractBACKGROUND:
Collagen XVIII is a ubiquitous basement membrane (BM) component and a precursor of endostatin.
METHODS:
Using immunohistochemistry and in situ hybridization, we studied the expression and localization of collagen XVIII in different stages of normal oral wound healing, epithelial dysplasia and squamous cell carcinoma (SCC).
RESULTS:
In mild epithelial dysplasias collagen XVIII appeared as a continuous signal in the BM, whereas in severe epithelial dysplasias and in the invasive areas of oral SCCs collagen XVIII was absent. In situ hybridization showed that collagen XVIII mRNA expression did not decrease in severe dysplasia or oral carcinoma samples when compared with the mild dysplasias.
CONCLUSIONS:
The results indicate that the absence of collagen XVIII protein in severe oral dysplasias is related to the processing of the protein rather than to changes in mRNA expression.
AuthorsAnu Väänänen, Merja Ylipalosaari, Mataleena Parikka, Tiina Kainulainen, Marko Rehn, Ritva Heljasvaara, Leo Tjäderhane, Tuula Salo
JournalJournal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (J Oral Pathol Med) Vol. 36 Issue 1 Pg. 35-42 (Jan 2007) ISSN: 0904-2512 [Print] Denmark
PMID17181740 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Angiogenesis Inhibitors
  • Collagen Type XVIII
  • Endostatins
  • RNA, Messenger
  • Matrix Metalloproteinase 9
Topics
  • Angiogenesis Inhibitors (analysis)
  • Basement Membrane (pathology)
  • Carcinoma, Squamous Cell (pathology)
  • Cell Line, Tumor
  • Cell Transformation, Neoplastic (pathology)
  • Collagen Type XVIII (analysis)
  • Endostatins (analysis)
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization
  • Matrix Metalloproteinase 9 (analysis)
  • Mouth Mucosa (pathology)
  • Mouth Neoplasms (pathology)
  • Neoplasm Invasiveness
  • Precancerous Conditions (pathology)
  • Protein Modification, Translational
  • RNA, Messenger (analysis)
  • Wound Healing (physiology)

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