HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Role of immunochemotherapy in the treatment of chronic lymphocytic leukemia.

Abstract
Major advances have been made in our understanding of the biology and opportunities for treatment of chronic lymphocytic leukemia in recent times. Newer treatment regimens incorporating purine nucleoside analogs have increased the rate of successful remission induction in chronic lymphocytic leukemia patients. Moreover, recent combination chemoimmunotherapy regimens have produced more frequent complete molecular remissions, and early evidence seems to suggest that this could result in prolonged duration of responses, although this association remains to be clearly demonstrated. This review will summarize recent advances in the biology and the management of chronic lymphocytic leukemia, including prognostic factors, pointing mainly on combination chemotherapy based on nucleoside analogs and monoclonal antibodies. In our opinion, in the future a significant improvement of clinical benefits in chronic lymphocytic leukemia will be obtained through the administration of cocktails of monoclonal antibodies combined with chemotherapy in different modalities.
AuthorsGiovanni Del Poeta, Maria Ilaria Del Principe, Francesco Buccisano, Luca Maurillo, Pasquale Niscola, Adriano Venditti, Sergio Amadori
JournalExpert review of anticancer therapy (Expert Rev Anticancer Ther) Vol. 6 Issue 12 Pg. 1787-800 (Dec 2006) ISSN: 1744-8328 [Electronic] England
PMID17181492 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Antibodies, Monoclonal
  • Antineoplastic Agents
  • Biomarkers, Tumor
  • Neoplasm Proteins
  • Chlorambucil
Topics
  • Aged
  • Antibodies, Monoclonal (therapeutic use)
  • Antineoplastic Agents (therapeutic use)
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Apoptosis
  • B-Lymphocytes (metabolism, pathology)
  • Biomarkers, Tumor
  • Cell Cycle
  • Chemotherapy, Adjuvant
  • Chlorambucil (therapeutic use)
  • Combined Modality Therapy
  • Female
  • Gene Rearrangement, B-Lymphocyte
  • Genes, Immunoglobulin
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Immunophenotyping
  • Immunotherapy
  • Leukemia, Lymphocytic, Chronic, B-Cell (diagnosis, drug therapy, surgery, therapy)
  • Male
  • Middle Aged
  • Neoplasm Proteins (metabolism)
  • Opportunistic Infections (etiology, prevention & control)
  • Prognosis
  • Survival Analysis

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: