Abstract | BACKGROUND AND PURPOSE: EXPERIMENTAL APPROACH: Rats were treated for 9 weeks with placebo or SB 239063 by gavage (15 mg kg(-1)) twice daily starting 7 days after ligation of the left anterior descending artery. Serial transthoracic echocardiography was performed at days 7, 36 and 70. KEY RESULTS: Over the 9 weeks, mortality was not different between the groups. On echocardiography, animals after myocardial infarction exhibited significant left ventricular dilatation as expected (week 10, end-systolic diameter, placebo sham 5.21+/- 0.34 vs. placebo MI 8.44+/- 0.57 mm). However, there was no difference between placebo and SB 239063-treated rats (week 10, end-systolic diameter, SB MI 7.76+/- 0.74 mm, not significantly different from placebo MI). Haemodynamics changed accordingly. Moreover, SB 239063 had no effect on left ventricular hypertrophy. Treatment with SB 239063 significantly reduced cytokine expression of tumour necrosis factor and interleukin-1beta after myocardial infarction. However, collagen content was not influenced by the treatment. CONCLUSION:
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Authors | S Frantz, T Behr, K Hu, D Fraccarollo, J Strotmann, E Goldberg, G Ertl, C E Angermann, J Bauersachs |
Journal | British journal of pharmacology
(Br J Pharmacol)
Vol. 150
Issue 2
Pg. 130-5
(Jan 2007)
ISSN: 0007-1188 [Print] England |
PMID | 17179956
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Imidazoles
- Pyrimidines
- p38 Mitogen-Activated Protein Kinases
- SB 239063
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Topics |
- Animals
- Imidazoles
(pharmacology)
- Inflammation
(prevention & control)
- Male
- Myocardial Infarction
(diagnostic imaging, mortality, physiopathology)
- Pyrimidines
(pharmacology)
- Rats
- Rats, Wistar
- Ultrasonography
- Ventricular Remodeling
- p38 Mitogen-Activated Protein Kinases
(antagonists & inhibitors, physiology)
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