A random clinical trial study to assess the efficiency of topical applications of podophyllin resin (25%) versus podophyllin resin (25%) together with acyclovir cream (5%) in the treatment of oral hairy leukoplakia.

Abstract

OBJECTIVE:

The objective of this study was to assess the efficiency of topical applications of podophyllin resin (25%) (P) versus podophyllin resin (25%) together with acyclovir cream (5%) (PA) in the treatment of oral hairy leukoplakia (OHL) in accordance with the following criteria: (1) number of applications necessary for the total clinical resolution of OHL; (2) correlation between the decrease of lesion size and the number of applications; (3) total clinical resolution of OHL; and (4) clinical reevaluation 12 months after the end of treatment.

STUDY DESIGN:

Forty-six OHLs were treated with P (P group) or with PA (PA group). Applications were performed weekly. Student t, Fisher exact, and Pearson correlation tests were used for statistical analysis.

RESULTS:

All 24 lesions from the PA group presented total clinical resolution while 4 lesions from the P group did not. The P group required up to 25 applications performed weekly while the PA group required up to 18. Observed was a negative significant association between the size of the lesions and the number of applications performed weekly in the PA group.

CONCLUSIONS:

The present study demonstrated the following: (1) P and PA topical treatments presented a similar average number of applications performed weekly; (2) both groups showed the same clinical response at 12 months post-therapy; and (3) PA presented a 100% clinical resolution and a continuous decrease in OHL size over the course of weekly applications.

• Authors: Mariela Dutra Gontijo Moura, Tatiane Roberta Morais Guimarães, Linaena Méricy Silva Fonseca, Isabela de Almeida Pordeus, Ricardo Alves Mesquita
• Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics (Oral Surg Oral Med Oral Pathol Oral Radiol Endod) Vol. 103 Issue 1 Pg. 64-71 (Jan 2007) ISSN: 1528-395X [Electronic] United States
• PMID: 17178496 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Antiviral Agents
• Keratolytic Agents
• Podophyllin
• Acyclovir

Topics

• Acyclovir (administration & dosage)
• Administration, Topical
• Adult
• Antiviral Agents (administration & dosage)
• Drug Therapy, Combination
• HIV Infections (complications)
• Humans
• Keratolytic Agents (administration & dosage)
• Leukoplakia, Hairy (drug therapy)
• Middle Aged
• Podophyllin (administration & dosage)