| Abstract | OBJECTIVE: To systematically review the scientific evidence derived from randomized controlled trials (RCT) about prevention of alveolar osteitis (AO). STUDY DESIGN: Literature searches were conducted to locate RCTs about prevention of AO. The RCTs were scrutinized for methodological details and categorized according to the preventive intervention studied. Data were analyzed in relation to the frequency of AO. Absolute risk reductions (ARR), and numbers needed to treat were calculated with 95% confidence limits. RESULTS: There was a wide variation in the design and quality of the RCTs (N = 32). The greatest risk reduction for AO was seen for local treatment with tetracycline (ARR, 12%-31%). For a majority of the preventive interventions, the evidence was absent or inconclusive. CONCLUSIONS: Local treatment with tetracycline, and also 0.12% chlorhexidine rinsing preoperatively and 7 days postoperatively, seem to have significant and clinically relevant preventive effect on AO following surgical removal of lower third molars. |
| Authors | Lennart Hedström, Petteri Sjögren
(Affiliation: Public Dental Services, Varberg, Sweden.)
|
| Journal | Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
(Oral Surg Oral Med Oral Pathol Oral Radiol Endod)
Vol. 103
Issue 1
Pg. 8-15
(Jan 2007)
ISSN: 1528-395X United States |
| PMID | 17178488
(Publication Type: Journal Article, Review)
|
| Chemical References |
- Anti-Bacterial Agents
- Anti-Infective Agents, Local
- Antifibrinolytic Agents
- Parabens
- Chlorhexidine
- Tetracycline
- propylparaben
|
| Topics |
- Anti-Bacterial Agents
(adverse effects, therapeutic use)
- Anti-Infective Agents, Local
(adverse effects, therapeutic use)
- Antifibrinolytic Agents
(therapeutic use)
- Chlorhexidine
(adverse effects, therapeutic use)
- Dry Socket
(drug therapy, prevention & control)
- Humans
- Parabens
(therapeutic use)
- Randomized Controlled Trials as Topic
(standards)
- Tetracycline
(adverse effects, therapeutic use)
- Tooth Extraction
(adverse effects)
|
