Serial sinus aspirate samples during high-dose, short-course levofloxacin treatment of acute maxillary sinusitis.

Abstract

This study assessed daily aspirate samples from an indwelling sinus catheter during high-dose, short-course levofloxacin (750 mg daily x 5 days) treatment of acute maxillary sinusitis. Pathogens were isolated from 4 of 18 recruited patients. Bacteriologic eradication occurred within 24 h for 3 patients and 72 h for the 4th.

• Authors: Jack B Anon, Margaret Paglia, Jim Xiang, Paul G Ambrose, Ronald N Jones, James B Kahn
• Journal: Diagnostic microbiology and infectious disease (Diagn Microbiol Infect Dis) Vol. 57 Issue 1 Pg. 105-7 (Jan 2007) ISSN: 0732-8893 [Print] United States
• PMID: 17178300 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Levofloxacin
• Ofloxacin

Topics

• Acute Disease
• Adult
• Anti-Bacterial Agents (administration & dosage, adverse effects, therapeutic use)
• Catheters, Indwelling
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Female
• Haemophilus Infections (drug therapy, microbiology)
• Haemophilus influenzae (drug effects, isolation & purification)
• Humans
• Levofloxacin
• Male
• Maxillary Sinusitis (drug therapy, microbiology)
• Microbial Sensitivity Tests
• Middle Aged
• Moraxella catarrhalis (drug effects, isolation & purification)
• Moraxellaceae Infections (drug therapy, microbiology)
• Ofloxacin (administration & dosage, adverse effects, therapeutic use)
• Pneumococcal Infections (drug therapy, microbiology)
• Streptococcus pneumoniae (drug effects, isolation & purification)
• Time Factors
• Treatment Outcome