Serial sinus aspirate samples during high-dose, short-course levofloxacin treatment of acute maxillary sinusitis.

This study assessed daily aspirate samples from an indwelling sinus catheter during high-dose, short-course levofloxacin (750 mg daily x 5 days) treatment of acute maxillary sinusitis. Pathogens were isolated from 4 of 18 recruited patients. Bacteriologic eradication occurred within 24 h for 3 patients and 72 h for the 4th.
AuthorsJack B Anon, Margaret Paglia, Jim Xiang, Paul G Ambrose, Ronald N Jones, James B Kahn
JournalDiagnostic microbiology and infectious disease (Diagn Microbiol Infect Dis) Vol. 57 Issue 1 Pg. 105-7 (Jan 2007) ISSN: 0732-8893 [Print] United States
PMID17178300 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Bacterial Agents
  • Levofloxacin
  • Ofloxacin
  • Acute Disease
  • Adult
  • Anti-Bacterial Agents (administration & dosage, adverse effects, therapeutic use)
  • Catheters, Indwelling
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Female
  • Haemophilus Infections (drug therapy, microbiology)
  • Haemophilus influenzae (drug effects, isolation & purification)
  • Humans
  • Levofloxacin
  • Male
  • Maxillary Sinusitis (drug therapy, microbiology)
  • Microbial Sensitivity Tests
  • Middle Aged
  • Moraxella (Branhamella) catarrhalis (drug effects, isolation & purification)
  • Moraxellaceae Infections (drug therapy, microbiology)
  • Ofloxacin (administration & dosage, adverse effects, therapeutic use)
  • Pneumococcal Infections (drug therapy, microbiology)
  • Streptococcus pneumoniae (drug effects, isolation & purification)
  • Time Factors
  • Treatment Outcome

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