Abstract |
Daily chlorhexidine mouthwash is often recommended for preventing chemotherapy-induced oral mucositis. Povidone-iodine, NaCl 0.9%, water salt soda solution and chamomile mouthwash are also recommended. However, the effectiveness of these mouthwashes is unclear. Therefore, we performed a systematic review to assess the effectiveness of mouthwashes in preventing and ameliorating chemotherapy-induced oral mucositis. Based on study quality, three out of five randomized controlled trials were included in a meta-analysis. The results failed to detect any beneficial effects of chlorhexidine as compared with sterile water, or NaCl 0.9%. Patients complained about negative side-effects of chlorhexidine, including teeth discoloration and alteration of taste in two of the five studies on chlorhexidine. The severity of oral mucositis was shown to be reduced by 30% using a povidone-iodine mouthwash as compared with sterile water in a single randomized controlled trial. These results do not support the use of chlorhexidine mouthwash to prevent oral mucositis.
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Authors | C M J Potting, R Uitterhoeve, W Scholte Op Reimer, T Van Achterberg |
Journal | European journal of cancer care
(Eur J Cancer Care (Engl))
Vol. 15
Issue 5
Pg. 431-9
(Dec 2006)
ISSN: 0961-5423 [Print] England |
PMID | 17177899
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Chemical References |
- Antineoplastic Agents
- Mouthwashes
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Topics |
- Antineoplastic Agents
(adverse effects)
- Humans
- Middle Aged
- Mouthwashes
(therapeutic use)
- Neoplasms
(drug therapy)
- Stomatitis
(chemically induced, prevention & control)
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