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The effectiveness of commonly used mouthwashes for the prevention of chemotherapy-induced oral mucositis: a systematic review.

Abstract
Daily chlorhexidine mouthwash is often recommended for preventing chemotherapy-induced oral mucositis. Povidone-iodine, NaCl 0.9%, water salt soda solution and chamomile mouthwash are also recommended. However, the effectiveness of these mouthwashes is unclear. Therefore, we performed a systematic review to assess the effectiveness of mouthwashes in preventing and ameliorating chemotherapy-induced oral mucositis. Based on study quality, three out of five randomized controlled trials were included in a meta-analysis. The results failed to detect any beneficial effects of chlorhexidine as compared with sterile water, or NaCl 0.9%. Patients complained about negative side-effects of chlorhexidine, including teeth discoloration and alteration of taste in two of the five studies on chlorhexidine. The severity of oral mucositis was shown to be reduced by 30% using a povidone-iodine mouthwash as compared with sterile water in a single randomized controlled trial. These results do not support the use of chlorhexidine mouthwash to prevent oral mucositis.
AuthorsC M J Potting, R Uitterhoeve, W Scholte Op Reimer, T Van Achterberg
JournalEuropean journal of cancer care (Eur J Cancer Care (Engl)) Vol. 15 Issue 5 Pg. 431-9 (Dec 2006) ISSN: 0961-5423 [Print] England
PMID17177899 (Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
Chemical References
  • Antineoplastic Agents
  • Mouthwashes
Topics
  • Antineoplastic Agents (adverse effects)
  • Humans
  • Middle Aged
  • Mouthwashes (therapeutic use)
  • Neoplasms (drug therapy)
  • Stomatitis (chemically induced, prevention & control)

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