[Cryotherapy is useful and safe in the prevention of oral mucositis after high-dose melphalan (L-PAM)].

Abstract

We prospectively assessed the effectiveness of cryotherapy after high-dose L-PAM to prevent oral mucositis. Cryotherapy with ice tips was commenced 15 minutes before L-PAM administration, and continued until the end of administration. Twenty-six patients were enrolled in this study. Thirteen patients with myeloma were treated with 200 mg/m2 L-PAM followed by autologous peripheral blood stem cell transplantation, and 13 patients (4 AML, 4 MDS, 2 ALL, 2 lymphoma and 1 CML) were treated with 140 mg/m2 L-PAM followed by allogeneic stem cell transplantation. Grade 1 mucositis occurred in four of 13 patients (31%) with 200 mg/m2 L-PAM, and 2 of 13 patients (16%) with 140 mg/m2 L-PAM. Only one patient had grade 2 mucositis, and no grade 3 mucositis were observed. The procedure was well tolerated in all patients. These data suggest that cryotherapy is effective to minimize L-PAM-induced oral mucositis.

• Authors: Noriko Inagaki, Yukiko Ohue, Hiroe Shigeta, Taizo Tasaka
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 47 Issue 11 Pg. 1469-71 (Nov 2006) ISSN: 0485-1439 [Print] Japan
• PMID: 17176891 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents, Alkylating
• Melphalan

Topics

• Adult
• Aged
• Antineoplastic Agents, Alkylating (adverse effects)
• Cryotherapy
• Female
• Humans
• Leukemia (therapy)
• Lymphoma (therapy)
• Male
• Melphalan (adverse effects)
• Middle Aged
• Stem Cell Transplantation
• Stomatitis (chemically induced, prevention & control)