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Real-world assessment of a metered-dose inhaler with integrated dose counter.

Abstract
Currently available metered dose inhalers (MDIs) do not track the remaining number of doses, indicating the need for a device that accurately monitors medication use. In an open-label study at 37 outpatient centers, patients > or =4 years old with asthma or chronic obstructive pulmonary disease requiring short-acting 32-agonists received two actuations of albuterol hydrofluoroalkane (HFA) [Ventolin HFA: GlaxoSmithKline], 90 microg twice daily, via a novel MDI with an integrated dose counter until all 200 actuations were completed. Concordance between counter readings, diary card-recorded actuations, and canister weights were measured in patients who completed > or =90% of the labeled actuations (n = 224). Adverse events and patient satisfaction were assessed in the intent-to-treat population (n = 268). In 43,865 recorded actuations, 333 counter versus diary discrepancies occurred (discrepancy rate of 0.76%), and 88% of discrepancies were by one to two actuations. Forty-seven percent of patients had no discrepancies. Incidence of the device firing without changes in counter readings was very low (0.09%). Mean expected actuations based on canister weights (184) were slightly lower than mean counter and diary-reported actuations (200 each). At baseline, 62% of patients reported anxiety about not knowing the quantity of medication remaining in their inhaler. On study completion, 92% expressed satisfaction with the dose counter and 92% agreed it would help prevent them from running out of medication. The adverse event profile showed that albuterol HFA was well tolerated. Integrated MDI counters are a useful and reliable tool for tracking a patient's medication supply.
AuthorsRichard L Wasserman, Ketan Sheth, William R Lincourt, Nicholas W Locantore, Jacqueline Carranza Rosenzweig, Courtney Crim
JournalAllergy and asthma proceedings (Allergy Asthma Proc) 2006 Nov-Dec Vol. 27 Issue 6 Pg. 486-92 ISSN: 1088-5412 [Print] United States
PMID17176783 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
Chemical References
  • Bronchodilator Agents
  • Albuterol
Topics
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Albuterol (administration & dosage, adverse effects)
  • Asthma (drug therapy)
  • Bronchodilator Agents (administration & dosage, adverse effects)
  • Child
  • Child, Preschool
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Female
  • Humans
  • Male
  • Metered Dose Inhalers
  • Middle Aged
  • Patient Satisfaction
  • Pulmonary Disease, Chronic Obstructive (drug therapy)

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