Effects of soybean glyceollins and estradiol in postmenopausal female monkeys.

Abstract

Glyceollins are a novel class of soybean phytoalexins with potential cancer-protective antiestrogenic effects. The purpose of this study was to evaluate the estrogen-antagonist effects of glyceollin-enriched soy protein on biomarkers for breast cancer risk. Thirty female postmenopausal cynomolgus macaques were randomized to one of three dietary treatments for 3 wk: 1) estradiol (E2, 1 mg/day) + casein/lactalbumin (control); 2) E2 + soy protein isolate (SPI) containing 194 mg/day isoflavonoids; and 3) E2 + glyceollin-enriched soy protein (GLY) containing 189 mg/day isoflavonoids + 134 mg/day glyceollins. Doses are expressed in calorically scaled human equivalents. Mean serum glyceollin concentrations at 4 h postfeeding were 134.2 +/- 34.6 nmol/L in the GLY group and negligible in the SPI group (P = 0.0007). Breast proliferation was significantly increased in the control group (+237%, P = 0.01) but not in the SPI group (+198%, P = 0.08) or GLY group (+36%, P = 0.18). Gene expression of trefoil factor 1 and progesterone receptor, two markers of estrogen receptor activity in breast epithelium, were also significantly higher in the control (P < 0.05 for both) but not in the GLY group. These preliminary findings suggest that soybean glyceollins are natural compounds with potential estrogen-modulating properties in the breast.

• Authors: Charles E Wood, Thomas B Clarkson, Susan E Appt, Adrian A Franke, Stephen M Boue, Matthew E Burow, Thomas McCoy, J Mark Cline
• Journal: Nutrition and cancer (Nutr Cancer) Vol. 56 Issue 1 Pg. 74-81 ( 2006) ISSN: 0163-5581 [Print] United States
• PMID: 17176220 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Anticarcinogenic Agents
• Benzopyrans
• Biomarkers
• Biomarkers, Tumor
• Isoflavones
• Peptides
• Pterocarpans
• Receptors, Progesterone
• Soybean Proteins
• Trefoil Factor-2
• Estradiol
• glyceollin

Topics

• Animals
• Anticarcinogenic Agents (pharmacology)
• Benzopyrans (blood, pharmacology)
• Biomarkers
• Biomarkers, Tumor
• Breast Neoplasms (blood, pathology, prevention & control)
• Estradiol (blood, pharmacology)
• Female
• Gene Expression
• Immunohistochemistry
• Isoflavones (blood, pharmacology)
• Macaca fascicularis (blood)
• Mammary Glands, Animal (drug effects, metabolism, pathology)
• Ovariectomy
• Peptides (metabolism)
• Postmenopause (blood)
• Pterocarpans
• Receptors, Progesterone (metabolism)
• Soybean Proteins (pharmacology)
• Soybeans (chemistry)
• Trefoil Factor-2