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Gardner's syndrome in a 40-year-old woman: successful treatment of locally aggressive desmoid tumors with cytotoxic chemotherapy.

AbstractBACKGROUND:
Desmoid tumors that present as a part of Gardener's syndrome can present very difficult management problems.
CASE PRESENTATION:
We report a case of intra-abdominal desmoid tumor causing distal small bowel obstruction that complicated the management of a more proximal enterocutaneous fistula from the jejunum. After failure of more conventional management options including imatinib, the patient's disease responded to doxorubicin and ifosfamide. The response resolved the bowel obstruction and allowed small intestinal resection to resolve the enterocutaneous fistula.
CONCLUSION:
Systemic cytotoxic therapy with doxorubicin and ifosfamide can be useful for patients with complications from intra-abdominal desmoid tumor.
AuthorsPrabhat K Bhama, Rashmi Chugh, Laurence H Baker, Gerard M Doherty
JournalWorld journal of surgical oncology (World J Surg Oncol) Vol. 4 Pg. 96 ( 2006) ISSN: 1477-7819 [Electronic] England
PMID17173703 (Publication Type: Journal Article)

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