[Effect of antioxidant use in dietary therapy in patients with chronic athrofic hastritis].

Abstract

In the 1-year double-blind placebo-controlled intervention trial, it was shown that daily supplementation of patients with gastric premalignant lesions (intestinal metaplasia, IM) with a complex, containing Ester-C with antioxidantsand (2100 mg of Ca-ascorbate + 340 mg of bioflavonoids), produced a sharp decrease of abnormally high ornithine decarboxylase activity in IM gastric mucosa that was accom panied by practically total IM regression in 11 of 18 (61%) patients.

• Authors: V A Draudin-Krylenko, A B Petukhov, Iu P Kuvshinov, A A Levchuk, Iu V Bukin
• Journal: Voprosy pitaniia (Vopr Pitan) Vol. 75 Issue 5 Pg. 53-5 ( 2006) ISSN: 0042-8833 [Print] Russia (Federation)
• PMID: 17172172 (Publication Type: Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Antioxidants
• Ornithine Decarboxylase
• Ascorbic Acid

Topics

• Adult
• Aged
• Antioxidants (administration & dosage)
• Ascorbic Acid (administration & dosage)
• Chronic Disease
• Double-Blind Method
• Female
• Gastric Mucosa (enzymology, microbiology, pathology)
• Gastritis, Atrophic (diet therapy, drug therapy, enzymology, pathology)
• Helicobacter Infections (diet therapy, drug therapy, enzymology)
• Humans
• Intestines (enzymology, pathology)
• Male
• Metaplasia (diet therapy, drug therapy, enzymology, pathology)
• Middle Aged
• Ornithine Decarboxylase (metabolism)