[Effective therapy with a glycine-proline ointment in a patient with recurrent ulcers from prolidase deficiency].

Abstract

INTRODUCTION:

Prolidase deficiency is a rare disease. Lower leg recalcitrant ulcerations are the most characteristic symptoms.

CASE REPORT:

Woman diagnosed of prolidase deficiency with leg recalcitrant and infected ulcerations. Dermatology service solicits a proline and glycline containing ointment after failing other topical treatment and a skin grafting. After initiation of treatment, ulcerations improved partially. FORMULA DESCRIPTION: According to "Real Decreto 175/2001, de 23 de febrero", Pharmacy service draws up an elaboration guide and a patient information leaflet of a proline 5%-glycine 5% water emulsive ointment.

DISCUSSION:

Topical application of a glycine-proline ointment is an alternative for the treatment of recalcitrant ulcerations and it has resulted in variable response. In our patient it has been effective, with a partial improvement of leg ulcerations and a decrease in admissions due to over infection.

• Authors: M P Ortega García, M A Cánoves Escolano, P Blasco Segura, M L García Melgares
• Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria (Farm Hosp) 2006 Sep-Oct Vol. 30 Issue 5 Pg. 304-8 ISSN: 1130-6343 [Print] Spain
• Vernacular Title: Tratamiento efectivo con un ungüento de glicina y prolina en un caso de úlceras recurrentes por déficit de prolidasa.
• PMID: 17166065 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Ointments
• Proline
• Dipeptidases
• proline dipeptidase
• Glycine

Topics

• Administration, Topical
• Amino Acid Metabolism, Inborn Errors (drug therapy, enzymology)
• Dipeptidases (deficiency)
• Female
• Glycine (metabolism, therapeutic use)
• Humans
• Leg Ulcer (drug therapy, enzymology)
• Middle Aged
• Ointments (administration & dosage)
• Proline (metabolism, therapeutic use)
• Secondary Prevention
• Treatment Outcome