[Process mechanism of Atractylodes macrocephala and conversion of sesquiterpenes].

Abstract

OBJECTIVE:

To research the process mechanism of Atractylodes macrocephala and conversion of sesquiterpenes from it.

METHOD:

The contents of atractylenolide I, II and III in the different processed herbal medicines were determined by HPLC. The conversion of the sesquiterpenes was proved by the separation of oxides of atractylone.

RESULT:

The contents of atractylenolide I and III increased after frying, and at high temperature the content of atract ylenolide III decreased. After oxidation, atractylone converted to atractylenolide I, III and biatractylenolide, and atractylenolide III converted to atractylenolide II after dehydration when heated.

CONCLUSION:

Atractylone can convert to atractylenolides during process of A. macrocephala, and the contents of each component are related to the level of process.

• Authors: Wei Li, Hong-Mei Wen, Xiao-Bing Cui, Ke-Wei Zhang
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 31 Issue 19 Pg. 1600-3 (Oct 2006) ISSN: 1001-5302 [Print] China
• PMID: 17165584 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Lactones
• Sesquiterpenes
• atractylenolide I
• atractylenolide II
• atractylenolide III

Topics

• Atractylodes (chemistry)
• Desiccation
• Hot Temperature
• Lactones (analysis, chemistry)
• Molecular Structure
• Oxidation-Reduction
• Plants, Medicinal (chemistry)
• Rhizome (chemistry)
• Sesquiterpenes (analysis, chemistry)
• Technology, Pharmaceutical (methods)
• Temperature