| Abstract | Extracts of Tripterygium wilfordii are effective in traditional Chinese medicine for treatment of rheumatoid arthritis (RA). Triptolide, a diterpenoid triepoxide purified from TWHF, has been identified as the major component of TWHF and might account for its therapeutic effects. To make for the clinical reasonable application and further development of triptolide, in this review was introduced the recent ten-years progress in mechanisms of anti-RA of it, including immunosuppression, anti-inflammation, inducing cell apoptosis, inhibiting vascular proliferation, protecting article cartilage and gene regulation. Triptolide is a potent immunosuppressant. |
| Authors | Chun-Fang Liu, Na Lin
(Affiliation: (Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.)
|
| Journal | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
(Zhongguo Zhong Yao Za Zhi)
Vol. 31
Issue 19
Pg. 1575-9
(Oct 2006)
ISSN: 1001-5302 China |
| PMID | 17165577
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't, Review)
|
| Chemical References |
- Cytokines
- Diterpenes
- Epoxy Compounds
- Immunosuppressive Agents
- NF-kappa B
- Phenanthrenes
- Dinoprostone
- triptolide
|
| Topics |
- Animals
- Apoptosis
(drug effects)
- Arthritis, Rheumatoid
(metabolism, pathology)
- Cell Proliferation
(drug effects)
- Cytokines
(metabolism)
- Dinoprostone
(metabolism)
- Diterpenes
(isolation & purification, pharmacology)
- Epoxy Compounds
(isolation & purification, pharmacology)
- Humans
- Immunosuppressive Agents
(pharmacology)
- NF-kappa B
(metabolism)
- Neovascularization, Pathologic
- Phenanthrenes
(isolation & purification, pharmacology)
- Plants, Medicinal
(chemistry)
- T-Lymphocytes
(pathology)
- Tripterygium
(chemistry)
|
