| Abstract | The most effective type of epilepsy surgery in adults is temporal lobe epilepsy (TLE) surgery. Three quarter of the patients become seizure free, however the remaining patients experience seizures after resection. In our study we analyzed retrospectively the possible electro-clinical, neuroimaging and surgery-related outcome predictors in 94 adult patients who had anterior temporal lobectomy (ATL) from the material of Epilepsy Centre of the National Institute of Psychiatry and Neurology, Budapest since the beginning of the surgery program in 1989 until 2001. Three outcome endpoints were chosen: the seizure status at the last visit, the longest seizure free period and the time to the first non-acute postoperative seizure. The predictors were assessed by multivariate and Cox regression methods. After one year of surgery 72% of the patients were seizure free, after two years 67% and after five years 59%. Factors predicting favorable outcome in TLE surgery were: typical temporomesial aura, strictly unilateral interictal anterotemporal spikes, unilateral ictal onset, slow contralateral propagation, hippocampal sclerosis (HS) as etiology. Factors predicting poor outcome in TLE surgery were: increase in seizure frequency in the last two preoperative years, presence of preoperative psychiatric disturbances, ictal contralateral propagation, MRI lesion distant from the surgery site, incongruency of data of preoperative investigations, postoperative sequels and non-HS type MR residuum. |
| Authors | Anna Kelemen, György Rásonyi, Anna Szucs, Dániel Fabó, Péter Halász
(Affiliation: Országos Pszichiátriai es Neurológiai Intézet, Budapest. kelemen at opni.hu)
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| Journal | Ideggyógyászati szemle
(Ideggyogy Sz)
Vol. 59
Issue 9-10
Pg. 353-9
(Sep 20 2006)
ISSN: 0019-1442 Hungary |
| Vernacular Title | A temporalis epilepszia mutétek kimenetelét elore jelzo tényezok vizsgálata. |
| PMID | 17165378
(Publication Type: English Abstract, Journal Article)
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| Topics |
- Adolescent
- Adult
- Anterior Temporal Lobectomy
- Epilepsy, Temporal Lobe
(surgery)
- Female
- Humans
- Male
- Middle Aged
- Multivariate Analysis
- Predictive Value of Tests
- Proportional Hazards Models
- Retrospective Studies
- Risk Factors
- Treatment Outcome
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