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[Evaluation of efficacy and safety of josamycin (Vilprafen) in the treatment of patients with community-acquired pneumonia].

Abstract
Clinical and bacteriological efficacy ofjosamycin (Vilprafen), a macrolide antibiotic, was studied in 30 out- and inpatients at the age of 18 to 68 years (the average of 43.4+/-16.7 years old) with nonsevere (PORT) community-acquired pneumonia in the case histories. Josamycin was administered orally in a dose of 500 mg every 8 hours for 7 to 10 days. The treatment course was 5 to 10 days (the average of 7.7+/-1.3 days). The recovery was stated in 28 (93.3%) patients and the pathogen eradication was recorded in 16 (88.9%) patients. Moderate side effects not requiring discontinuation of the drug use were observed in 3 patients. The results of the treatment were indicative of the josamycin high efficacy in the treatment of the patients with nonsevere community-acquired pneumonia.
AuthorsS V Iakovlev, M A Aleksandrova, M P Suvorova, S A Kostina
JournalAntibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] (Antibiot Khimioter) Vol. 51 Issue 3-4 Pg. 47-8, 50-2 ( 2006) ISSN: 0235-2990 [Print] Russia (Federation)
PMID17165259 (Publication Type: Clinical Trial, English Abstract, Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Josamycin
Topics
  • Adolescent
  • Adult
  • Aged
  • Anti-Bacterial Agents (administration & dosage, adverse effects, therapeutic use)
  • Community-Acquired Infections (drug therapy, etiology)
  • Evaluation Studies as Topic
  • Female
  • Gram-Negative Bacteria (isolation & purification)
  • Gram-Positive Bacteria (isolation & purification)
  • Humans
  • Josamycin (administration & dosage, adverse effects, therapeutic use)
  • Male
  • Middle Aged
  • Pneumonia, Bacterial (drug therapy, microbiology)
  • Prospective Studies

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