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Intrahepatic mRNA levels of type I interferon receptor and interferon-stimulated genes in genotype 1b chronic hepatitis C. Association between IFNAR1 mRNA level and sustained response to interferon therapy.

AbstractOBJECTIVE:
The aim of this study was to determine the association between pretreatment intrahepatic mRNA levels of interferon receptor and interferon-stimulated genes and response to interferon therapy for genotype 1b chronic hepatitis C.
METHODS:
Forty-four patients with genotype 1b chronic hepatitis C who underwent liver biopsy and then received interferon therapy participated in this study. Pretreatment intrahepatic mRNA levels of interferon receptor genes (IFNAR1, IFNAR2b, and IFNAR2c) and interferon-stimulated genes (OAS1 and PKR) were quantified by competitive polymerase chain reaction.
RESULTS:
In the genes examined, only IFNAR1 mRNA level was significantly higher in patients with sustained virological and biochemical response to interferon therapy versus those with nonsustained response (p < 0.01). Moreover, mRNA expression ratios of IFNAR1 to IFNAR2 were also significantly higher in patients with sustained virological and biochemical response to IFN therapy (p < 0.01 and p < 0.05, respectively). On the other hand, mRNA levels of IFNAR2b, IFNAR2c, and PKR were significantly higher in patients with histologically active or advanced liver rather than patients with mild or less advanced liver.
CONCLUSIONS:
High intrahepatic mRNA levels of IFNAR1 and mRNA ratio of IFNAR1 to IFNAR2 before treatment may be associated with a favorable response to interferon therapy.
AuthorsHideaki Taniguchi, Yoshiaki Iwasaki, Akira Takahashi, Hiroyuki Shimomura, Akio Moriya, Piao Cheng Yu, Fumi Umeoka, Shin-ichi Fujioka, Norio Koide, Yasushi Shiratori
JournalIntervirology (Intervirology) Vol. 50 Issue 1 Pg. 32-9 ( 2007) ISSN: 0300-5526 [Print] Switzerland
PMID17164555 (Publication Type: Journal Article)
CopyrightCopyright 2007 S. Karger AG, Basel.
Chemical References
  • Antiviral Agents
  • IFNAR1 protein, human
  • Interferon-alpha
  • RNA, Messenger
  • RNA, Viral
  • Receptor, Interferon alpha-beta
  • Interferon-beta
  • eIF-2 Kinase
  • OAS1 protein, human
  • 2',5'-Oligoadenylate Synthetase
Topics
  • 2',5'-Oligoadenylate Synthetase (genetics, metabolism)
  • Adult
  • Antiviral Agents (pharmacology, therapeutic use)
  • Female
  • Hepatitis C, Chronic (drug therapy, pathology, virology)
  • Humans
  • Interferon-alpha (pharmacology, therapeutic use)
  • Interferon-beta (pharmacology, therapeutic use)
  • Liver (metabolism, pathology)
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • RNA, Messenger (genetics, metabolism)
  • RNA, Viral (blood)
  • Receptor, Interferon alpha-beta (genetics, metabolism)
  • Treatment Outcome
  • eIF-2 Kinase (genetics, metabolism)

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