Abstract | BACKGROUND: METHODS: We prospectively examined the associations between the intakes of fruits, vegetables, vitamins A, C, and E, and carotenoids and risk of renal cell cancer in women and men. We followed 88,759 women in the Nurses' Health Study from 1980 to 2000, and 47,828 men in the Health Professionals Follow-up Study from 1986 to 2000. We assessed dietary intake every 2 to 4 years using a validated semiquantitative food frequency questionnaire. The Cox proportional hazards model was used to estimate study-specific multivariate relative risks (RR), which were pooled using a random effects model. RESULTS: A total of 248 (132 women and 116 men) incident renal cell cancer cases were ascertained during 2,316,525 person-years of follow-up. The consumption of fruits and vegetables was associated with a decreased risk of renal cell cancer in men (multivariate RR, 0.45; 95% CI, 0.25-0.81, for >or=6 servings of fruit and vegetable intake/d versus <3 servings/d; P test for trend = 0.02), but not in women (multivariate RR, 1.17; 95% CI, 0.66-2.07, for the same contrast; P test for trend = 0.25; P test for between-studies heterogeneity = 0.02). Intakes of vitamins A and C from food and carotenoids were inversely associated with the risk of renal cell cancer in men only, but we cannot exclude the possibility that this was due to other factors in fruit and vegetables. No clear association was observed for vitamin E in women or men. CONCLUSIONS:
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Authors | Jung Eun Lee, Edward Giovannucci, Stephanie A Smith-Warner, Donna Spiegelman, Walter C Willett, Gary C Curhan |
Journal | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
(Cancer Epidemiol Biomarkers Prev)
Vol. 15
Issue 12
Pg. 2445-52
(Dec 2006)
ISSN: 1055-9965 [Print] United States |
PMID | 17164369
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Antioxidants
- Vitamins
- Vitamin A
- Vitamin E
- Carotenoids
- Ascorbic Acid
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Topics |
- Adult
- Antioxidants
- Ascorbic Acid
- Carcinoma, Renal Cell
(epidemiology)
- Carotenoids
- Diet Records
- Female
- Fruit
- Health Surveys
- Humans
- Middle Aged
- Prospective Studies
- Risk Assessment
- Sex Factors
- United States
(epidemiology)
- Vegetables
- Vitamin A
- Vitamin E
- Vitamins
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