Abstract | OBJECTIVE: This study aimed to compare the clinical efficacy of two anti-inflammatory medications ( fenspiride and inhaled beclomethasone [ beclomethasone dipropionate]) in patients with stable chronic obstructive pulmonary disease ( COPD) over 6 months. DESIGN, METHODS AND PATIENTS: This was a randomised comparison of 58 patients with COPD, divided into five treatment groups: fenspiride (stages 1 and 2), beclomethasone (stage 2), and two control groups (stages 1 and 2). In addition, 64 patients with exacerbations of COPD were evaluated over a 2-week treatment period during which they received either fenspiride or prednisolone. Clinical signs and symptoms of COPD were evaluated every 2 months (aggregated numerical index of signs and symptoms), as were lung function tests (forced vital capacity [FVC], forced expiratory volume in 1 second [FEV1], FEV1/FVC) and a 6-minute walking test. RESULTS: Statistically significant reductions in all evaluated COPD signs and symptoms were achieved with fenspiride in stage 1 COPD. Fenspiride therapy significantly reduced the indices of sputum parameters (8-fold decrease), incidence of dry rales (6-fold decrease), dyspnoea (4-fold decrease) and cough (2.5-fold decrease). In comparison with beclomethasone, fenspiride was superior in stage 2 COPD. In patients with stage 2 COPD, reductions were less marked, but remained significantly superior in the fenspiride group in comparison with the beclomethasone group and the control groups. In patients with exacerbations of COPD, fenspiride had equivalent efficacy to that of systemic corticosteroids. CONCLUSION:
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Authors | E I Shmelev, Yu L Kunicina |
Journal | Clinical drug investigation
(Clin Drug Investig)
Vol. 26
Issue 3
Pg. 151-9
( 2006)
ISSN: 1173-2563 [Print] New Zealand |
PMID | 17163246
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Spiro Compounds
- Beclomethasone
- fenspiride
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Topics |
- Adult
- Aged
- Anti-Inflammatory Agents
(therapeutic use)
- Beclomethasone
(administration & dosage, adverse effects)
- Drug Therapy, Combination
- Female
- Forced Expiratory Volume
(drug effects)
- Humans
- Male
- Middle Aged
- Pulmonary Disease, Chronic Obstructive
(drug therapy, physiopathology)
- Spiro Compounds
(administration & dosage, adverse effects)
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