Abstract | BACKGROUND:
Tempamine is one of new class of antioxidant agents, the nitroxides, which have shown a wide range of biological effects like suppressing free radical driven reactions to maintain cell functions. The objectives of this study were to evaluate the effect of a biodegradable polymer coated stent loaded with tempamine on in- stent neointimal formation. METHODS: RESULTS: Histomorphometric analysis showed that the bare, polymer-only and tempamine-coated stents elicited a similar tissue response at 5 days. At 6 weeks, the peri-strut inflammation and neointimal hyperplasia of polymer-only stents were comparable to the bare stents. Compared to the bare stents, 50% tempanine coated stents had a trend to decrease the arterial injury (0.62 +/- 0.41 versus 0.34 +/- 0.18, P = 0.075) and neointimal hyperplasia (1.80 +/- 0.77 versus 1.27 +/- 0.39 mm2, P = 0.085). However, 100% tempanine coated showed significantly increased inflammatory response and neointimal formation. CONCLUSION: These co- PEA polymer coatings showed a biocompatible performance. Loaded with 50% tempamine had a trend to decrease neointimal hyperplasia. The 100% tempamine for stent-based delivery may have potential cytotoxic effects to arterial wall. Using a co- PEA polymer topcoat could effectively abolish these side effects.
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Authors | Yanming Huang, Lan Wang, Shengqiao Li, Xiaoshun Liu, Kwangdeok Lee, Eric Verbeken, Frans van de Werf, Ivan de Scheerder |
Journal | Acute cardiac care
(Acute Card Care)
Vol. 8
Issue 4
Pg. 210-6
( 2006)
ISSN: 1748-2941 [Print] England |
PMID | 17162547
(Publication Type: Journal Article)
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Chemical References |
- Coated Materials, Biocompatible
- Cyclic N-Oxides
- Polymers
- Stainless Steel
- 4-amino-TEMPO
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Topics |
- Analysis of Variance
- Animals
- Coated Materials, Biocompatible
- Cyclic N-Oxides
(administration & dosage, pharmacology)
- Drug Delivery Systems
- Microscopy, Electron, Scanning
- Polymers
- Stainless Steel
- Stents
- Swine
- Tunica Intima
(drug effects)
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