Abstract |
Antibodies against heat shock protein 90beta (Hsp90beta) recognize the antigen on the surface of oligodendrocyte precursor cells and induce a decrease in the oligodendrocyte population of cell cultures. This study investigated the presence of anti-Hsp90beta antibodies in patients with multiple sclerosis (MS) during remission. Anti-Hsp90beta antibodies were detected in the cerebrospinal fluid (CSF) of patients with a specific and sensitive western blot procedure using Hsp90beta from cell membrane fraction. The number of patients with anti-Hsp90beta antibodies detected in the CSF was significantly greater in MS patients than in control patients with other neurological diseases, which included patients with other inflammatory neurological diseases. CSF anti-Hsp90beta antibody levels were significantly higher in MS patients than in control patients. The presence of anti-Hsp90beta antibodies in the CSF of MS patients during remission could suggest a potential pathogenic role for these autoantibodies in MS.
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Authors | C Cid, I Regidor, A Alcázar |
Journal | Journal of neuroimmunology
(J Neuroimmunol)
Vol. 184
Issue 1-2
Pg. 223-6
(Mar 2007)
ISSN: 0165-5728 [Print] Netherlands |
PMID | 17161872
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies
- HSP90 Heat-Shock Proteins
- HSP90AB1 protein, human
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Topics |
- Adult
- Antibodies
(cerebrospinal fluid)
- Blotting, Western
(methods)
- Cell Line, Tumor
- Female
- HSP90 Heat-Shock Proteins
(immunology)
- Humans
- Male
- Middle Aged
- Multiple Sclerosis
(cerebrospinal fluid, immunology)
- Neuroblastoma
(pathology)
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