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Dose-related effects of direct hemoperfusion using a cytokine adsorbent column for the treatment of experimental endotoxemia.

AbstractOBJECTIVE:
To clarify the dose-related effects of direct hemoperfusion using a cytokine adsorbent column (CTR) on the mortality and inflammatory responses to endotoxin-induced shock in rats.
DESIGN:
Prospective and randomized study.
SETTING:
University research laboratory.
SUBJECTS:
Male Wistar rats.
INTERVENTIONS:
Forty-eight rats were injected intravenously with Escherichia coli endotoxin (15 mg/kg over 2 min), and then were randomly allocated to one of the following four groups (n = 12 per group): control group, treated without CTR for 120 min; quarter-dose treatment group, treated with CTR 0.25 ml for 120 min; half-dose treatment group, treated with CTR 0.50 ml; and full-dose treatment group, treated with CTR 1.0 ml.
MEASUREMENTS AND RESULTS:
Hemodynamics and arterial blood gases were recorded, and mortality and plasma cytokine concentrations were calculated for the 8-h observation period. The mortality rates 8 h after endotoxin injection were 92%, 58%, 42% and 17% for the control column, quarter-dose, half-dose, and full-dose CTR groups, respectively. The increases in plasma cytokine concentrations were smaller in the half-dose and full-dose CTR treatment groups than in the endotoxemic group.
CONCLUSIONS:
The present study showed that CTR treatment dose-dependently decreased the mortality rate and inhibited inflammatory responses in vivo.
AuthorsTakumi Taniguchi, Akihide Kurita, Chisui Mukawa, Ken Yamamoto, Hideo Inaba
JournalIntensive care medicine (Intensive Care Med) Vol. 33 Issue 3 Pg. 529-33 (Mar 2007) ISSN: 0342-4642 [Print] United States
PMID17160419 (Publication Type: Evaluation Study, Journal Article)
Chemical References
  • Cytokines
  • Interleukin-6
  • Tumor Necrosis Factor-alpha
Topics
  • Analysis of Variance
  • Animals
  • Cytokines (blood)
  • Endotoxemia (blood, therapy)
  • Hemoperfusion (methods)
  • Interleukin-6
  • Male
  • Prospective Studies
  • Random Allocation
  • Rats
  • Rats, Wistar
  • Shock, Septic (blood, therapy)
  • Survival Analysis
  • Tumor Necrosis Factor-alpha

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