Abstract |
Principal rotenoids ( deguelin, tephrosin, rotenone, and 12a-hydroxyrotenone) (3-30microM) isolated from the stems of Erycibe expansa significantly inhibited invasion of human fibrosarcoma HT1080 cells through Matrigel-coated filters and release of proMMPs-2 and 9. In addition, deguelin and tephrosin showed differentiation-inducing activity in human promyelocytic leukemia HL-60 cells. Furthermore, effects of various constituents isolated from the ethyl acetate-soluble fraction on proliferation of human leukemia U937 cells were examined. As a result, most of isoflavones and several flavans as well as rotenoids showed moderate or substantial anti-proliferative activities.
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Authors | Hisashi Matsuda, Kazutoshi Yoshida, Katsutoshi Miyagawa, Yasunobu Asao, Saya Takayama, Souichi Nakashima, Fengming Xu, Masayuki Yoshikawa |
Journal | Bioorganic & medicinal chemistry
(Bioorg Med Chem)
Vol. 15
Issue 3
Pg. 1539-46
(Feb 01 2007)
ISSN: 0968-0896 [Print] England |
PMID | 17158054
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Enzyme Precursors
- Flavonoids
- Plant Extracts
- Rotenone
- Gelatinases
- Metalloendopeptidases
- pro-matrix metalloproteinase 9
- progelatinase
- Matrix Metalloproteinase 9
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Topics |
- Cell Differentiation
(drug effects)
- Cell Proliferation
(drug effects)
- Convolvulaceae
(chemistry)
- Enzyme Precursors
(metabolism)
- Fibrosarcoma
(drug therapy, pathology)
- Flavonoids
(pharmacology)
- Gelatinases
(metabolism)
- HL-60 Cells
(drug effects)
- Humans
- Matrix Metalloproteinase 9
(metabolism)
- Metalloendopeptidases
(metabolism)
- Neoplasm Invasiveness
(prevention & control)
- Plant Extracts
(chemistry, pharmacology)
- Rotenone
(chemistry, pharmacology)
- Tumor Cells, Cultured
(drug effects)
- U937 Cells
(drug effects)
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