Reduced severity of experimental autoimmune encephalomyelitis in GMF-deficient mice.

Abstract	Glia maturation factor (GMF), a highly conserved brain-specific protein, isolated, sequenced and cloned in our laboratory. Overexpression of GMF in astrocytes induces the production and secretion of granulocyte-macrophage-colony stimulating factor (GM-CSF), and subsequent immune activation of microglia, expression of several proinflammatory genes including major histocompatibility complex proteins, IL-1beta, and MIP-1beta, all associated with the development of experimental autoimmune encephalomyelitis (EAE), the animal model for multiple sclerosis. Based on GMF's ability to activate microglia and induce well-established proinflammatory mediators, including GM-CSF, we hypothesize that GMF is involved in the pathogenesis of inflammatory disease EAE. In this present investigation, using GMF-deficient mice, we study the role of GMF and how the lack of GMF affects the EAE disease. Our results show a significant decrease in incidence, delay in onset, and reduced severity of EAE in GMF-deficient mice, and support the hypothesis that GMF plays a major role in the pathogenesis of disease.
Authors	Asgar Zaheer, Smita Zaheer, Shailendra K Sahu, Baoli Yang, Ramon Lim
Journal	Neurochemical research (Neurochem Res) Vol. 32 Issue 1 Pg. 39-47 (Jan 2007) ISSN: 0364-3190 [Print] United States
PMID	17151915 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References	Glia Maturation Factor Mog protein, mouse Myelin Proteins Myelin-Associated Glycoprotein Myelin-Oligodendrocyte Glycoprotein Peptide Fragments Tumor Necrosis Factor-alpha Granulocyte-Macrophage Colony-Stimulating Factor Nitric Oxide Synthase Type II Nos2 protein, mouse
Topics	Animals Encephalomyelitis, Autoimmune, Experimental (physiopathology) Female Glia Maturation Factor (deficiency) Granulocyte-Macrophage Colony-Stimulating Factor (biosynthesis) Mice Mice, Knockout Myelin Proteins Myelin-Associated Glycoprotein (immunology) Myelin-Oligodendrocyte Glycoprotein Nitric Oxide Synthase Type II (biosynthesis) Peptide Fragments (pharmacology) Tumor Necrosis Factor-alpha (biosynthesis)

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