Abstract | BACKGROUND: AIM: METHODS: DBA/1J mice with collagen-induced arthritis were treated with cortistatin after the onset of disease, and the clinical score and joint histopathology were evaluated. Inflammatory response was determined by measuring the levels of various inflammatory mediators ( cytokines and chemokines) in joints and serum. T helper cell type 1 (Th1)-mediated autoreactive response was evaluated by determining the proliferative response and cytokine profile of draining lymph node cells stimulated with collagen and by assaying the content of serum autoantibodies. RESULTS: CONCLUSION: This work provides a powerful rationale for the assessment of the efficacy of cortistatin as a novel therapeutic approach to the treatment of rheumatoid arthritis.
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Authors | Elena Gonzalez-Rey, Alejo Chorny, Raimundo G Del Moral, Nieves Varela, Mario Delgado |
Journal | Annals of the rheumatic diseases
(Ann Rheum Dis)
Vol. 66
Issue 5
Pg. 582-8
(May 2007)
ISSN: 0003-4967 [Print] England |
PMID | 17151007
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Collagen Type II
- Cytokines
- Immunoglobulins
- Neuropeptides
- Receptors, G-Protein-Coupled
- Receptors, Ghrelin
- Receptors, Somatostatin
- cortistatin
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Topics |
- Animals
- Anti-Inflammatory Agents
(immunology, therapeutic use)
- Arthritis, Experimental
(drug therapy, immunology)
- Collagen Type II
(immunology)
- Cytokines
(drug effects, immunology)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Down-Regulation
(immunology)
- Immunoglobulins
(blood)
- Mice
- Mice, Inbred DBA
- Neuropeptides
(immunology, therapeutic use)
- Receptors, G-Protein-Coupled
(immunology)
- Receptors, Ghrelin
- Receptors, Somatostatin
(immunology)
- Severity of Illness Index
- Synovial Membrane
(immunology, pathology)
- Th1 Cells
(immunology)
- Treatment Outcome
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