Electrochemotherapy of Mycosis fungoides by interferon-alpha.

Abstract

Eight patients with 29 lesions of histologically verified 1st stage of Mycosis fungoides were successfully treated by electrochemotherapy with interferon-alpha. For this purpose 8 biphasic pulses were used, each of 50+50 micros duration with 900 micros interpulse intervals, resulting in a burst of 7.1 ms total duration. Compared to the traditional monoimmunotherapy with interferon-alpha applied three times weekly for a total of 4 weeks, the electrochemotherapy was very efficient. Complete response (CR) was observed in 25 (86%) of the 29 treated lesions by single-act electrochemotherapy with interferon-alpha. At the end of the 12-month period, all 29 lesions showed 100% complete response (CR). New lesions for a period of 12 months were not observed. The expected mechanism involved in multiple cytotoxic action of interferon-alpha could be the local increased concentration in the tumour and prolongation of the time of its action after the application of pulses.

• Authors: E Peycheva, I Daskalov, I Tsoneva
• Journal: Bioelectrochemistry (Amsterdam, Netherlands) (Bioelectrochemistry) Vol. 70 Issue 2 Pg. 283-6 (May 2007) ISSN: 1567-5394 [Print] Netherlands
• PMID: 17150416 (Publication Type: Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Angiogenesis Inhibitors
• Antineoplastic Agents
• Interferon-alpha

Topics

• Angiogenesis Inhibitors (administration & dosage)
• Antineoplastic Agents (administration & dosage)
• Electrochemotherapy (methods)
• Humans
• Injections, Intralesional (methods)
• Interferon-alpha (administration & dosage)
• Mycosis Fungoides (drug therapy, pathology)
• Skin Neoplasms (drug therapy, pathology)
• Treatment Outcome