Abstract | OBJECTIVE: To evaluate the relationship between 99mTc-HL91 (99mTc labeled 4,9-diaza-3,3,10,10-tetramethyldodecan-2,11-dione dioxime) SPECT (single photon emission computed tomography) hypoxia imaging and the treatment outcome and also to assess changes in tumor oxygenation during the course of radiotherapy. METHODS: RESULTS: The relationship between T/N ratios at 4 hours images after injection that was shown as the best of 3 acquired images before radiotherapy and tumor response and over survival were analyzed for all 32 patients. The results of 99mTc-HL91 imaging of 32 patients correlate well with tumor response (P = 0.002) and also patient survival (P = 0.043). The T/N ratios of 18 patients were decreased before, during and after radiotherapy and there was significant statistic difference (P = 0.000...). CONCLUSIONS:
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Authors | Ling Li, Jinming Yu, Ligang Xing, Kefeng Ma, Hui Zhu, Hongbo Guo, Xindong Sun, Jianbin Li, Guoren Yang, Wanlong Li, Jinbo Yue, Baosheng Li |
Journal | American journal of clinical oncology
(Am J Clin Oncol)
Vol. 29
Issue 6
Pg. 628-33
(Dec 2006)
ISSN: 1537-453X [Electronic] United States |
PMID | 17149002
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Organotechnetium Compounds
- Oximes
- Radiopharmaceuticals
- technetium Tc 99m 4,9-diaza-3,3,10,10-tetramethyldodecan-2,11-dione dioxime
- Oxygen
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Topics |
- Adult
- Aged
- Carcinoma, Non-Small-Cell Lung
(diagnostic imaging, radiotherapy)
- Cell Hypoxia
- Female
- Humans
- Lung Neoplasms
(diagnostic imaging, radiotherapy)
- Male
- Middle Aged
- Organotechnetium Compounds
- Oximes
- Oxygen
(analysis)
- Predictive Value of Tests
- Prognosis
- Prospective Studies
- Radiopharmaceuticals
- Radiotherapy, Conformal
- Survival Analysis
- Tomography, Emission-Computed, Single-Photon
- Treatment Outcome
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