We investigated the influence of
N-stearoylethanolamine (NSE) on
tumor growth and
metastasis of the lung Lewis
carcinoma in mice. The effect of NSE on
lipid composition of lung tissue under tumorogenesis was also studied. We demonstrated that NSE inhibited the
tumor growth and decreased the volume and quantity of
metastases being administered from the fourth day after injection of
tumor cells to the last day of experiment and being administrated from the 21th day after injection of
tumor cells to the last day of the experiment. The analysis of the
lipid composition of the lung tissue showed the decrease of total
phospholipid levels and change of the
phospholipid spectra under
tumor growth. The decreasing of the concentration of
phosphatidylcholine, sphyngomyeline,
phosphatidylserine and
lysophosphatidylcholine in the lung tissue of
tumor-bearding mice in comparison with lung of intact animals was observed. It was found that administration of NSE increased the level of
lysophosphatidylcholine and decreased the concentration of
phosphatidylinositol in investigated tissues. The content of
sphingosine was increased in lung tissue of mice fed by NSE in comparison with
tumor-bearing mice. The
carcinoma development was associated by the significant decreasing of
cholesterol level and by the increasing of
unsaturated fatty acids in membrane
phospholipids. The amount of the tiobarbituric
acid (TBA) reactive substances in
tumor-bearing mice was elevated. The administration of NSE inhibited the accumulation of TBA reacting compounds.