Abstract | PURPOSE: We have identified the phytoalexin compounds glyceollins I, II, and III, which exhibit marked antiestrogenic effects on estrogen receptor function and estrogen-dependent tumor growth in vivo. The purpose of this study was to investigate the interactions among the induced soy phytoalexins glyceollins I, II, and III on the growth of estrogen-dependent MCF-7 breast cancer and BG-1 ovarian cancer cells implanted in ovariectomized athymic mice. EXPERIMENTAL DESIGN: Four treatment groups for each cell line were used: vehicle control, 20 mg/kg/mouse/d glyceollin mixture injection, 0.72 mg estradiol (E2) implant, and E2 implant + 20 mg/kg/mouse/d glyceollin injection. RESULTS: Treatment with glyceollin suppressed E2-stimulated tumor growth of MCF-7 cells (-53.4%) and BG-1 cells (-73.1%) in ovariectomized athymic mice. These tumor-inhibiting effects corresponded with significantly lower E2-induced progesterone receptor expression in the tumors. In contrast to tamoxifen, the glyceollins had no estrogen-agonist effects on uterine morphology and partially antagonized the uterotropic effects of estrogen. CONCLUSIONS: These findings identify glyceollins as antiestrogenic agents that may be useful in the prevention or treatment of breast and ovarian carcinoma.
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Authors | Virgilo A Salvo, Stephen M Boué, Juan P Fonseca, Steven Elliott, Cynthia Corbitt, Bridgette M Collins-Burow, Tyler J Curiel, Sudesh K Srivastav, Betty Y Shih, Carol Carter-Wientjes, Charles E Wood, Paul W Erhardt, Barbara S Beckman, John A McLachlan, Thomas E Cleveland, Matthew E Burow |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 12
Issue 23
Pg. 7159-64
(Dec 01 2006)
ISSN: 1078-0432 [Print] United States |
PMID | 17145841
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Benzopyrans
- Estrogen Receptor Modulators
- Pterocarpans
- Receptors, Progesterone
- Estradiol
- glyceollin
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Topics |
- Animals
- Benzopyrans
(administration & dosage, chemistry, pharmacology)
- Breast Neoplasms
(drug therapy, pathology)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Disease Models, Animal
- Estradiol
(administration & dosage)
- Estrogen Receptor Modulators
(administration & dosage, chemistry, pharmacology)
- Female
- Humans
- Mice
- Mice, Nude
- Ovarian Neoplasms
(drug therapy, pathology)
- Predictive Value of Tests
- Pterocarpans
- Receptors, Progesterone
(biosynthesis, drug effects)
- Structure-Activity Relationship
- Transplantation, Heterologous
- Uterus
(drug effects, pathology)
- Xenograft Model Antitumor Assays
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