Abstract | OBJECTIVES: The Italian Society of Hematology (SIE) and two affiliate societies (SIES and GITMO) commissioned a project to develop clinical practice guidelines for the treatment of chronic lymphocytic leukemia (CLL). METHODS: Key questions in the management of patients with CLL were formulated by an Advisory Committee and approved by an Expert Panel of eight senior hematologists. After a systematic review of the literature, recommendations for disease-specific and supportive therapies were formulated and graded according to the supporting evidence. Explicit consensus methods were used for providing recommendations for questions with incomplete or potentially biased evidence. RESULTS: CONCLUSIONS: We describe the results of a systematic literature review and an explicit approach to consensus techniques which resulted in recommendations for the key therapeutic decisions in patients with CLL.
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Authors | Maura Brugiatelli, Giuseppe Bandini, Giovanni Barosi, Francesco Lauria, Vincenzo Liso, Monia Marchetti, Francesca Romana Mauro, Giovanna Meloni, Pier Luigi Zinzani, Sante Tura, Italian Society of Hematology, Italian Society of Experimental Hematology, Italian Group for Bone Marrow Transplantation |
Journal | Haematologica
(Haematologica)
Vol. 91
Issue 12
Pg. 1662-73
(Dec 2006)
ISSN: 1592-8721 [Electronic] Italy |
PMID | 17145603
(Publication Type: Journal Article, Practice Guideline, Research Support, Non-U.S. Gov't)
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Topics |
- Bone Marrow Transplantation
(standards)
- Disease Management
- Hematology
(standards)
- Humans
- Italy
- Leukemia, Lymphocytic, Chronic, B-Cell
(diagnosis, therapy)
- Societies, Medical
(standards)
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